IRCT2015102624713N1 IRCT 2016-03-09 Vice chancellor for research,Zahedan University of Medical Sciences Effectiveness of pentoxifylline in contrast induced nephropathy Effectiveness of oral pentoxifylline for the prevention of contrast nephropathy in CKD patients undergoing coronary angiography 2016-01-09 anticipated 60 Complete https://irct.ir/trial/20804 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2 Contrast Nephropathy. Intervention 1: In the control group N-acetylcysteine 1200 mg administered every 12 hours in addition to hydration will be prescribed. Intervention 2: In the intervention group, prescribed pentoxifylline 400 mg every 8 hours plus hydration and NAC In the control group , prescription N-acetylcysteine 1200 mg every 12 hours is recommended in addition to hydration.

public Mahmoud Kordi

Ali-ebn Abi Taleb Hospital,Salamat Blvd, Dr.Hesabi Sq.,Daneshgah Ave., Zahedan zahedan

Zahedan Iran (Islamic Republic of) +98 54 3328 7533 gharibeh.0001@gmail.com Zahedan Medical University scientific Ali Alidadi

Ali Ebn Abitaleb Hospital, Salamt Blvd, Dr.Hesabi Sq., Daneshgah Ave.,Zahedan

Zahedan Iran (Islamic Republic of) +98 54 3329 5636 drali.alidadi@yahoo.com Zahedan Medical University Iran (Islamic Republic of) Inclusion criteria of ckd patients with angiography and cardiac catheterization indication include:Age greater than 18 and less than 75 years,Patient satisfaction for the study Exclusion criteria include : problems in patients follow up, treatment with theophylline, furosemide, mannitol or dopamine in last one month,use of Nonsteroidal anti-inflammatory drugs, aminoglycosides, N-acetylcysteine drugs,Renal failure patients with serum creatinine equal to or less than 1.5 mg per deciliter, Patients with an allergy to contrast material, Patients with Multiple myeloma, Pulmonary edema, Uncontrolled hypertension, patient required emergency angiography, diagnostic use of radiocontrast material for patient in the last 2 months of other diagnostic reasons, congestive heart failure,pregnancy, lactation Sensitivity to the NAC or pentoxifylline 18 years 75 years Both N17, N18, Renal failure Treatment - Drugs Treatment - Drugs In the control group N-acetylcysteine 1200 mg administered every 12 hours in addition to hydration will be prescribed In the intervention group, prescribed pentoxifylline 400 mg every 8 hours plus hydration and NAC In the control group , prescription N-acetylcysteine 1200 mg every 12 hours is recommended in addition to hydration Serum Creatine. Timepoint: at admission, 24 h after intervention. Method of measurement: blood test based on miligram on decilitre. Contrast Nephropathy. Timepoint: 24 houres. Method of measurement: blood test based on miligram on decilitre. Vice chancellor for research,Zahedan University of Medical Sciences Approved 2015-09-23 Ethics Committee of Zahedan Medical University of Science Ethics Committee of Zahedan Medical University of Science, Zahedan Medical University of Science, Dr.Hesabi Square, Daneshgah Avenue, Zahedan Zahedan Iran (Islamic Republic of)