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IRCT2015101824576N1 IRCT 2016-06-10 Vice Chancellor for research of Zahedan University of Medical Sciences Oral memantine and pain after orthopedic surgery Comparison the effect of pre-operative oral memantine and placebo on pain following orthopedic surgery 2015-06-22 anticipated 110 Complete https://irct.ir/trial/20711 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Patients needing orthopedic surgery of the lower limbs below the knee. Intervention 1: Intervention 1: In the intervention group 20 mg of memantine were administrated one hour before surgery for the patient. Intervention 2: Intervention 2: In the control group placebo were administrated (a capsule containing starch inside the shed) one hour before surgery for the patient.
public Khalil Souloki
School of Medicine - Zahedan University of Medical Sciences - Janet Boulevard – Dr. Hesabi Square – Zahedan
Zahedan Iran (Islamic Republic of) +98 54 3329 5796 solokikhalil@yahoo.com Zahedan University of Medical Sciences scientific Seyed Mohamad Nasialdin Tabatabaei
School of Medicine - Zahedan University of Medical Sciences - Janet Boulevard – Dr. Hesabi Square – Zahedan
Zahedan Iran (Islamic Republic of) +98 54 3329 5796 Ar_dashipoor@yahoo.com Zahedan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria including age range between 18 and 60 years, having indications for spinal anesthesia, having surgery of the lower limbs below the knee for bone plaque embedding. Exclusion criteria including any postoperative complication requires surgical intervention, lack of consent to participate in the study, having a history of substance abuse, history of chronic disease such as diabetes, high blood pressure and etc. taking medication, having a mental illness, having known hypersensitivity to the ketamine drug, having mental retardation and loss of consciousness, hemodynamic disorders, bleeding disorders and anemia 18 years 60 years Both S80-S99 Injury, poisoning and certain other consequences of external causes Treatment - Drugs Treatment - Drugs Intervention 1: In the intervention group 20 mg of memantine were administrated one hour before surgery for the patient. Intervention 2: In the control group placebo were administrated (a capsule containing starch inside the shed) one hour before surgery for the patient. Pain intensity. Timepoint: 30 and 60 minutes, 2, 12 and 24 hours after surgery. Method of measurement: VAS (Visual Analogue Scale) ruler. Consumption of Analgesic amount. Timepoint: 30 and 60 minutes, 2, 12 and 24 hours after surgery. Method of measurement: mg. Vice Chancellor for research of Zahedan University of Medical Sciences Approved 2015-01-21 Ethics committee of Zahedan University of Medical Sciences School of Medicine - Zahedan University of Medical Sciences - Janet Boulevard – Dr. Hesabi Square - Zahedan Zahedan Iran (Islamic Republic of)