]>
IRCT2015101224493N1 IRCT 2016-01-25 Clinical Research Developmental Unit, Imam Hossein Medical and educational Hospital, Shahid Behesht Local dexmedetomidine in awake fiberoptic intubation - Studying the effect of Dexmedetomidine as local anesthetic adjuvant on sedation and hemodynami status of patients during fiberoptic nasotracheal intubation 2015-08-23 anticipated 96 Complete https://irct.ir/trial/20660 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Other, Purpose: Treatment, Other design features: Random Number Table. N/A the quality of awake fiberoptic intubation. Intervention 1: Control group:airway nerve blocks by lidocaine (5 milligram per kilogram of body weight) and infusion of 20 cc normal saline over 10 minutes before the blocks. Intervention 2: DEX LOCAL group: infusion of 20 cc normal saline over 10 minutes before the above procedures, and 1 microgram per kilgram of body weight dexmedetomidine (Hospira, USA) added to the total volume of lidocaine (5 miligram per kilogram of body weight) used in blocks as an adjuvant . Intervention 3: DEX IV group: intravenous infusion of 1 microgram per kilogram of body weight dexmedetomidine (Hospira, USA) in a 20 cc syringe over 10 minutes before blocks, airway nerve blocks by lidocaine (5 milligram per kilogram of body weight).
public Parisa Sezari MD
No 2, 10th floor, 8th tower block, Hormozan avenue, Shahrake gharbsquare, Tehran, Iran
Tehran Iran (Islamic Republic of) +98 912 219 4036 psezari@sbmu.ac.ir; parissasezari@yahoo.com Shahid Beheshti University of MedicalSciences scientific Alireza Mirkheshti , MD
Pasdaran street, Tehran, Iran
Tehran Iran (Islamic Republic of) +98 912 343 5962 a_mirkheshti@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: 18-66 year old; ASA class 1 or 2; elective surgery; probable difficult airway; probable injury to cervical spine Exclusion criteria: ASA >3; history of any cardiac disease; history of hypertension; history of renal function impairment; history of liver function impairment; history of opiod/recreational drug abuse; using anti hypertension drugs; usig alpha adrenergic agonists or antagonists; history of any psychological disorders; pregnancy; NPO time less than 8 hours for solid food and less than 3 hours for clear fluids; baseline heart rate less than 60 beats per minute; emergent/urgent surgeries; overt coagulopathy or impaired coagulation tests; history of diabetes mellitus 18 years 66 years Both - - Treatment - Drugs Treatment - Drugs Treatment - Drugs Control group:airway nerve blocks by lidocaine (5 milligram per kilogram of body weight) and infusion of 20 cc normal saline over 10 minutes before the blocks DEX LOCAL group: infusion of 20 cc normal saline over 10 minutes before the above procedures, and 1 microgram per kilgram of body weight dexmedetomidine (Hospira, USA) added to the total volume of lidocaine (5 miligram per kilogram of body weight) used in blocks as an adjuvant . DEX IV group: intravenous infusion of 1 microgram per kilogram of body weight dexmedetomidine (Hospira, USA) in a 20 cc syringe over 10 minutes before blocks, airway nerve blocks by lidocaine (5 milligram per kilogram of body weight) Propofol consumption (milligrams per kilogram of body weight). Timepoint: at the time of reaching CSI score=75. Method of measurement: observation. Intubation scores. Timepoint: at the time of bronchoscopy and intubation. Method of measurement: observation. Clinical Research Developmental Unit, Imam Hossein Medical and educational Hospital, Shahid Behesht Approved 2015-09-22 Ethics committee of Sِhahid Beheshti University of Medical Sciences Koudakyar steet, Daneshgah square, Velenjak, Tehran, Iran Tehran Iran (Islamic Republic of)