IRCT2015100324327N1 IRCT 2016-01-13 Vice chancellor for research, Babol university of Medical Sciences The effect of of Kaaser capsule (Zingiber Oficinale, Caum Capticum, Piper Nigrum) on bloating. The effect of Kaaser capsule (Zingiber Officinale, Carum Capticum, Piper Nigrum) on functional bloating and comparison with Dimethicone capsule; Clinical Control Trial. 2016-01-21 anticipated 120 Complete https://irct.ir/trial/20558 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Bloating. Intervention 1: Intervention group 1: Kaaser capsule (Zingiber Officinae, Carum Copticum, Piper Nigrum), 500 mg, TDS, 2 weeks. Intervention 2: Intrventional group2:Dimethicone capsul consisted of 40mg Dimethicone,TDS,2 weeks. Intervention 3: Interventional group3:Placebo capsul,500mg,TDS,2weeks.

public Zeinab Mahmoudpour

Ganjafrooz street,Babol

Babol Iran (Islamic Republic of) 47176-47745 +98 11 3219 4728 Z.mahmoudpour@mubabol.ac.ir Mahmoudpour.zeinab@gmail.com Babol university of medical sciences scientific Dr Seyed Ali Mozaffarpour

Ganjafrooz street, Babol

Babol Iran (Islamic Republic of) 47176-47745 +98 11 3219 4728 Seyyedali1357@gmail.com Babol university of medical sciences Iran (Islamic Republic of) Inclusion criteria: age of 20 to 50 years, symptoms of bloating: feeling of abdominal distention, increasing of abdominal gas in the last three months with symptom onset at least six months prior to the study, three days a week؛ Exclusion criteria :I.B.D on colonoscopy, Diabetes, Anemia, Hypothyroidism, Celiac, Kidney disease,use of any treatment of bloating on during the study. 20 years 50 years Both R14 Flatulence and related conditions Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: Kaaser capsule (Zingiber Officinae, Carum Copticum, Piper Nigrum), 500 mg, TDS, 2 weeks. Intrventional group2:Dimethicone capsul consisted of 40mg Dimethicone,TDS,2 weeks Interventional group3:Placebo capsul,500mg,TDS,2weeks Severity of bloating. Timepoint: before study, two weeks after starting the study, two weeks and two months after finishing the study. Method of measurement: Visual Analogue Scale. Frequency of bloating. Timepoint: Befor study,two weeks after starting the study,two weeks and two mounths after finishing the study. Method of measurement: Visual Analogue Scale. Early satiety. Timepoint: 2 weeks afrer starting the study. Method of measurement: Visual Analogue Scale. Vice chancellor for research, Babol university of Medical Sciences Approved 2015-12-06 Ethics Committee of Babol university of medical science Ethics. Babol- Ganjafrooz street- university of Babol Babol Iran (Islamic Republic of)