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IRCT2015092924268N1 IRCT 2015-12-07 Vice Chancellor For Research of Tehran Medical School, Tehran University of Medical Sciences Comparison of nerve blocks and epidural anesthesia on stress response in patients undergoing general anesthesia Comparison of the efficacy of TAP Block and Epidural A. on post operative stress response of elective laparoscopic cholecystectomy surgery in shariati hospital -1393 2015-12-06 anticipated 52 Complete https://irct.ir/trial/20528 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. N/A General Anesthesia. Intervention 1: At the beginning of surgery before anesthesia induction, TAP BLOCK performed by the Professor of Anesthesiology and with the method of Ultrasound guided Transversus Abdominus plane block with 20 cc Bupivacaine 0.5%. Intervention 2: Initially with 2cc lidocaine 2%, local anesthesia were created then through the number 18 epidural needle inserted into the epidural space then made sure of the correct position of epidural space, 25 cc Bupivacaine 0.25% will be injected.
public Piroozeh Taheri
Dr shariati Hospital, Jalal Al Ahmad Street, Northen Kargar Street, Tehran
Tehran Iran (Islamic Republic of) +98 21 8822 0032 ven_17@yahoo.com Anesthesiology Department, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran scientific Ali Movafegh
Anesthesiology Department, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran
Tehran Iran (Islamic Republic of) +98 21 8822 0032 movafegh@sina.tums.ac.ir Department of Anesthesiology Iran (Islamic Republic of) Inclusion criteria: Age 18-50 years; BMI<30; Stage 1 and 2 ASA; Surgery time less than 2 hours; Absence of systemic disease such as (heart or lung disease and serious liver-Kidney disease); Absence of contraindications to epidural anesthesia (coagulopathies, infection at needle insertion site, The patient's lack of cooperation, Absence of consent); Absence of any contraindications to perform Block; Absence of a history of immunosuppressive and corticosteroid drugs; Absence of a history of drug addiction and smoking. Exclusion criteria: Failing to block; Incidence of complications during surgery and laparotomy for any reason; Prolongation of operation (more than 2 hours) 17 years 49 years Both T41.1, T41 Intravenous Anesthetics, Other and Unspecified General Anesthetic, Local Anesthetics Prevention Prevention At the beginning of surgery before anesthesia induction, TAP BLOCK performed by the Professor of Anesthesiology and with the method of Ultrasound guided Transversus Abdominus plane block with 20 cc Bupivacaine 0.5% Initially with 2cc lidocaine 2%, local anesthesia were created then through the number 18 epidural needle inserted into the epidural space then made sure of the correct position of epidural space, 25 cc Bupivacaine 0.25% will be injected. Objective success rate of blockage for anesthesia by injection and deposition of sediment material (Marcaine) between the layers of muscle (IOM and TAM). Timepoint: During of surgery. Method of measurement: Ultrasound sonography. The Subjective Success Rate of Block. Timepoint: 30 minute. Method of measurement: Check the skin sensation of the same area of block in the epigastric and umbilical and groin. Pain. Timepoint: Immediately, 6, 12, 24 hours after discharge from recovery. Method of measurement: Visualized Analogue Scale. Blood Sugar ,WBC , CRP , Cortisol, TNF-α and IL-1 level of serum. Timepoint: Before induction of anesthesia and 6 and 24 hours after extubation of patient. Method of measurement: Blood Exam. Vice Chancellor For Research of Tehran Medical School, Tehran University of Medical Sciences Approved 2015-10-11 Vice Chancellor For Research of Tehran Medical School, Tehran University of Medical Sciences Vice Chancellor For Research of Tehran Medical School, Tehran University of Medical Sciences, Poursina Street, Keshavarz Blvd, Tehran Tehran Iran (Islamic Republic of)