IRCT2015091323998N1 IRCT 2015-10-25 Vice chancellor for research, Tehran University of Medical Sciences Efficacy of short message services on treatment adherence, severity of depression and spiritual health in depressed patients A clinical trial for comparison the effects of sending one-way short message, interactive short message and not sending any message on adherence to medication, depression, and spiritual health among patients with major depression 2015-10-22 anticipated 90 Complete https://irct.ir/trial/20360 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Other design features: Participants are going to be non randomly allocated to three groups. N/A Condition 1: Depressive episode. Condition 2: Depressive episode. Intervention 1: Control group: The patients in control group will not be received any short messages. Intervention 2: Non- interactive message group: In this group the patients receive every day hopeful message derived from traditions and elite, and tips about side effects, percussion, and medication reminder for 6 weeks. Intervention 3: Interactive message group: In this group the patients receive every day hopeful message derived traditions and elite, and tips about side effects, percussion, and medication reminder, to which should be answered by the patient using short message for 6 weeks.