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IRCT2015091123978N1 IRCT 2017-11-05 Shiraz University of Medical Sciences Effect ot Fenugreek in treatment of Acne Vulgaris Comparison of the efficacy of oral Trigonella foenum-graecum seed extract and oral azithromycin in the severity of acne vulgaris; a randomized controlled clinical trial 2015-07-23 anticipated 20 Complete https://irct.ir/trial/20347 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 0 (exploratory trials) Acne vulgaris. Intervention 1: Intervention group, in addition to diet and hygienic recommendations, use capsules containing fenugreek hydro alcoholic extract 1g / d for 2 months. Intervention 2: Control group, in addition to diet and hygienic recommendations, use Azithromycin capsules 250mg/d for 2 months.
public Ali Mohammadi
Zand street, School of Medicine
Shiraz Iran (Islamic Republic of) +98 917 736 9270 dr.mohammadi71@gmail.com Shiraz university of medical science scientific Mojdeh Sepaskhah
Karim Khan Street, Faghighi Hospital, Molecular Dermatology research center
Shiraz Iran (Islamic Republic of) +98 71 3212 5592 Sepaskhah_m@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: age 12 to 30 years; GAGS score between 1 and 30; signature consent form. Exclusion criteria: previous consumption of oral acne controller medications, such as antibiotics, isotretinoin, oral contraceptive pills; administration of drugs that caused acne such as testosterone, progesterone, steroids, lithium, phenytoin, and isoniazid; patients with symptoms of endocrine disorders especially hyperandrogegism, including polycystic ovarian syndrome (oligomenorrhea, polycystic ovaries, hirsutism), Cushing syndrome (rapid weight gain, buffalo hump, moon face, excess sweating, purple or red striae on the body and hirsutism), CAH, androgen-secreting tumors, and acromegaly; severe skin problem; women who were pregnant or lactating. 12 years 30 years Both L70.0 Acne vulgaris Treatment - Drugs Treatment - Drugs Intervention group, in addition to diet and hygienic recommendations, use capsules containing fenugreek hydro alcoholic extract 1g / d for 2 months. Control group, in addition to diet and hygienic recommendations, use Azithromycin capsules 250mg/d for 2 months. Severity of skin lesions. Timepoint: At baseline, 30 and 60 days after intervention. Method of measurement: Global Acne Grading System (GAGS). Changes in lesions count (total, inflammatory, non-inflammatory and regional). Timepoint: At baseline, 30 and 60 days after intervention. Method of measurement: visual counting. Shiraz University of Medical Sciences Approved 2014-09-02 Shiraz University of Medical Sciences Shiraz University of Medical Sciences, Zand street Shiraz Iran (Islamic Republic of)