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IRCT2015090223864N1 IRCT 2015-10-19 Tehran University of Medical Sciences The treatment of Acne Vulgaris Comparison of theraputic effects of Tea Tree Oil nanoemulsion gel containing adapalene with commercial form of adapalene gel for the treatment of acne vulgaris 2016-05-01 anticipated 160 Complete https://irct.ir/trial/20293 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 acne vulgaris. Intervention 1: Topical tea tree oil nanoemulsion loaded 0.1% adapalene gell, one times daily on the clean skin for 3 months. Intervention 2: Topical adapalene gell 0.1%, one times daily on the clean skin for 3 months.
public Roqiye Najafi-Taher
Eastern side of Tehran University, 88, Italia St,The School of Advanced Technologies in Medicine (SATiM),Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 8899 1118 r-najafitaher@razi.tums.ac.ir Tehran University of Medical Sciences scientific Dr. Amir Amani
Eastern side of Tehran University of Medical sciences, 88E, Italia St, The school of Advance Technologies in Medicine(SATiM), Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 8899 1117 aamani@sina.tums.ac.ir Tehran University of Medical sciences Iran (Islamic Republic of) Inclusion criteria: Presence of mild to moderate Acne Vulgaris (up to 10 comedons, papular and/or pustular lesions). Exclusion criteria: pregnant and lactating women, children younger than 15 years old, severe cases of acne (existence of nodules and cysts), receiving anti acne during two weeks prior to study, taking acne creating drugs such as oral or local steroids, spirnolactone, finasteride. Patient with diabetes mellitus, endocrine disorder. 15 years 40 years Both L70 acne vulgaris Treatment - Drugs Treatment - Drugs Topical tea tree oil nanoemulsion loaded 0.1% adapalene gell, one times daily on the clean skin for 3 months Topical adapalene gell 0.1%, one times daily on the clean skin for 3 months Inflammatory and noninflammatory lesions. Timepoint: Baseline and after 4,8, and 12 weeks. Method of measurement: counting lesions using manual lens. Side effect. Timepoint: Baseline and after 4, 8, and 12 weeks. Method of measurement: case report form. Tehran University of Medical Sciences Approved 2015-07-29 Tehran University of Medical Sciences Keshavarz Boulevard, Tehran, Iran Tehran Iran (Islamic Republic of)