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IRCT2015090223855N1 IRCT 2015-10-27 Vice- Chancellor for Research, Semnan University of Medical Sciences Comparision of clinical efficacy of Intravenous acetaminophen vs ketorolac to relieve pain in renal colic Comparision of clinical efficacy of Intravenous acetaminophen vs ketorolac to relieve pain in renal colic 2015-09-23 anticipated 120 Complete https://irct.ir/trial/20282 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Acute Renal Colic. Intervention 1: Intervention group: patients will receive 30 mg intravenous ketorolac tromethamine (brand name : ketorolac ,Caspian Tamin Pharmaceutical Company) within 15 seconds. Intervention 2: Control group: patients will receive 1 gram intravenous paracetamol (brand name : Apotel) infused in 100 ml normal saline within 15 minutes.
public Dr Davood Arab
Kosar Hospita, Bassije Blvd, Semnan
Semnan Iran (Islamic Republic of) 3519899951 +98 23 3343 7830 drdavoodarab@semums.ir Semnan University of Medical Sciences scientific Dr Davood Arab
Kosar hospital, Bassije Blvd, Semnan
Semnan Iran (Islamic Republic of) 3519899951 +98 23 3343 7830 drdavoodarab@semums.ir Semnan University of Medical Sciences Iran (Islamic Republic of) Patients will eligible for inclusion with a history of unilateral abdominal or flank pain that the treating emergency physicians suspect to be renal colic, with ultrasonography or CT Scan or intravenous pyelography (IVP) findings consistent with the diagnosis of renal colic or passage of the calculus. Only patients displaying at least a visual analog scale (VAS) ≥30/100 will include. Patients can not be include if they have a history of peptic ulcer disease, asthma, bleeding disorder (including the use of oral anticoagulant), impaired renal or hepatic function, suspected hypersensivity to aspirin or NSAID or paracetamol, and if they are pregnant and breast-feeding women. Patients can not be include if they have received painkillers within 6 hours before presentation and if they are younger than 18 and greater than 55 years old. 18 years 55 years Both N20.9 Urinary calculus, unspecified Treatment - Drugs Treatment - Drugs Intervention group: patients will receive 30 mg intravenous ketorolac tromethamine (brand name : ketorolac ,Caspian Tamin Pharmaceutical Company) within 15 seconds. Control group: patients will receive 1 gram intravenous paracetamol (brand name : Apotel) infused in 100 ml normal saline within 15 minutes. Level of pain. Timepoint: before treatment initiation and sequentially at 20,40,60 minutes. Method of measurement: Visual Analogue Scale. Heart Rate. Timepoint: before treatment initiation and sequentially at 20,40,60 minutes. Method of measurement: Radial Pulse. Blood pressure. Timepoint: before treatment initiation and sequentially at 20,40,60 minutes. Method of measurement: sphygmomanometer. Body temprature. Timepoint: before treatment initiation and sequentially at 20,40,60 minutes. Method of measurement: Thermometer(axillary). Respiratory rate. Timepoint: before treatment initiation and sequentially at 20,40,60 minutes. Method of measurement: Physical examination. Size of renal calculi. Timepoint: after pain relief. Method of measurement: imaging findings. Location of renal calculi. Timepoint: after pain relief. Method of measurement: imaging findings. Paracetamol side effects. Timepoint: in all the time in care. Method of measurement: questionnaire and physical examination. Ketorolac side effects. Timepoint: in all the time in care. Method of measurement: questionnaire and physical examination. Vice- Chancellor for Research, Semnan University of Medical Sciences Approved 2015-08-25 Ethics Ccommittee of Semnan University of Medical Sciences Kosar Hospital, Bassije Blvd, Semnan, Iran Semnan Iran (Islamic Republic of)