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IRCT201709042365N17 IRCT 2017-09-23 Iran University of Medical Sciences The effects of Zn, vitamin A and magnesium supplementation on patients with hypothyroidism zinc AND vitamin A and magnesium and hypothyroidism The effects of Zn, vitamin A and magnesium supplementation on anthropometric parameters, metabolic, thyroid hormones, oxidative stress and hs-CRP in patients with hypothyroidism 2017-10-01 anticipated 88 Complete https://irct.ir/trial/2025 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. 3 hypothyroidism. Intervention 1: Dietary Zinc supplement, 30 mg/d، Dietary vitamin A supplement, 25000 IU twice a week and Dietary magnesium supplement, 250 mg/d for 10 weeks. Intervention 2: Placebo, the same as zinc tablet as the active supplement with the same size, daily for 10 weeks، Placebo, the same as magnesium tablet as the active supplement with the same size, daily for 10 weeks and Placebo, the same as vitamin A capsule as the active supplement with the same size, twice a week for 10 weeks.
public Dr Mohammad Reza Vafa
Nutrition Department, School of Public Health, Iran University of Medical Sciences, Hemat Express way
tehran Iran (Islamic Republic of) +98 21 8670 4743 vafa.m@iums.ac.ir; rezavafa@yahoo.com Iran University of Medical Sciences scientific Dr Mohammad Reza Vafa
Nutrition Department, School of Public Health, Iran University of Medical Sciences, Hemat Express way
tehran Iran (Islamic Republic of) +98 21 8670 4743 vafa.m@iums.ac.ir; rezavafa@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) Hypothyroid patients referring to Endocrine and Metabolism Research Institute of Iran University of Medical Sciences who have the following criteria and express their willingness to cooperate. Inclusion criteria: patients consensus; age 20 to 65 years old; BMI < 30 kg/m2; Drug therapy with levothyroxine; Exclusion Criteria: Unwillingness to continue the study; compliance below the 80 percent; having history of Diabetes; Hypertension; cardiovascular diseases; gastrointestinal diseases; anemia; pregnant or lactating women; alcohol consumer or Cigarette smoker, Taking any supplements including vitamins & minerals in last 3 months; digestive complications for supplements; Changing the dosage of the drug in the study 20 years 65 years Both E03.9 Hypothyroidism, unspecified Treatment - Other Placebo Dietary Zinc supplement, 30 mg/d، Dietary vitamin A supplement, 25000 IU twice a week and Dietary magnesium supplement, 250 mg/d for 10 weeks Placebo, the same as zinc tablet as the active supplement with the same size, daily for 10 weeks، Placebo, the same as magnesium tablet as the active supplement with the same size, daily for 10 weeks and Placebo, the same as vitamin A capsule as the active supplement with the same size, twice a week for 10 weeks Thyroid Hormones. Timepoint: Before intervention and 10 weeks after intervention. Method of measurement: ELIZA. MDA. Timepoint: Before intervention and 10 weeks after intervention. Method of measurement: measurement kit. Hs-CRP. Timepoint: Before intervention and10 weeks after intervention. Method of measurement: ELIZA. Body Composition. Timepoint: Before intervention and 10 weeks after intervention. Method of measurement: Body Composition Analyser. Basal Metabolic Rate. Timepoint: Before intervention and 10 weeks after intervention. Method of measurement: Body Composition Analyser. TAC. Timepoint: Before intervention and 10 weeks after intervention. Method of measurement: measurement kit. Iran University of Medical Sciences Approved 2017-09-02 Iran University of Medical Sciences Hemmat Highway, IUMS Tehran Iran (Islamic Republic of)