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IRCT2016011423473N2 IRCT 2016-06-06 Vice Chancellor for research Qazvin University of Medical Sciences Comparison of post-operative analgesic effect of adding Dexmedetomidine or dexamethasone to lidocaine through local anastasia in forearm surgery Comparison of post operative analgesic effect of adding Dexmedetomidine or dexamethasone to lidocaine through infraclavicular block in forearm surgery. 2015-09-23 anticipated 75 Complete https://irct.ir/trial/20010 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. N/A Forearm laceration. Intervention 1: In group 1, 28 cc lidocaine 1.5% plus 2cc distilled water will administer. Intervention 2: In group 2, 28 cc lidocaine 1.5% plus 8mg Dexamethasone will administer. Intervention 3: In group 3, 28 cc lidocaine 1.5% plus 1μgr/kg Dexmedetomidine will administer.
public Dr. Hoda Shehamat
Rajee Hospital, Padegan Avenu, Qzvin
Qazvin Iran (Islamic Republic of) +98 28 3332 0105 hoda_shahamat@yahoo.com Qazvin University of Medical Sciences scientific Dr. Siamak Yaghoubi
Rajee Hospital ; Padegan Avenu ; Qzvin
Qazvin Iran (Islamic Republic of) +98 28 3332 0105 Drsiamakyaghoubi@gmail.com Qazvin University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients 20–60 years old; with American Society of Anesthesiologists (ASA) physical status I or II; scheduled for elective forearm surgery. Exclusion criteria: Presence of underlying diseases such as coagulopathy, peripheral vascular diseases and neuropathy; patient’s avoidance; any history of allergy to local anesthetics; treatment with palliative drugs and those affecting the CNS; addiction; neurologic deficit in respective organ; infection in the site of injection; pregnancy; BMI˂20 & BMI>40; the use of drugs which interfere with lidocaine such as beta blockers, cimetidine, phenytoin. 20 years 60 years Both S54, S56 Injury of nerves at forearm level, Injury of muscle and tendon at forearm level Placebo Prevention Prevention In group 1, 28 cc lidocaine 1.5% plus 2cc distilled water will administer. In group 2, 28 cc lidocaine 1.5% plus 8mg Dexamethasone will administer In group 3, 28 cc lidocaine 1.5% plus 1μgr/kg Dexmedetomidine will administer. Pain. Timepoint: In 2, 4 and 6 hours after infraclavicular block. Method of measurement: Visual analogue Scales(VAS). Total analgesic dose administered. Timepoint: During 6 hrs after the infraclavicular block ( With interval 2hrs). Method of measurement: Patient file. Onset of sensory and motor block. Timepoint: From the start of anesthetics injection. Method of measurement: Evaluate the patient’s response to needle hitting on surgical site and griping force. Time of duration of sensory block. Timepoint: The time interval between the time of loss of pain sensation at forearm to reappearance of paresthesia. Method of measurement: Pin-prick test. Hemodynamic variables of the block. Timepoint: In 5, 10, 15, 20 and 30 minutes after infraclavicular block. Method of measurement: Monitoring system. Time of duration of motor block. Timepoint: The time interval between the time of loss of pain sensation at forearm to complete recovery of motor function. Method of measurement: Gripping force test. Vice Chancellor for research Qazvin University of Medical Sciences Approved 2016-01-10 Ethics Committee of the University of Medical Sciences Qazvin, Shahid Bahonar Blvd Qazvin Iran (Islamic Republic of)