IRCT2015070623104N1 IRCT 2016-05-05 Mashhad University of Medical Sciences, research assisstance Effect of mechanical ventilation on intracranial pressure Airway Pressure Release Ventilation Effect of airway pressure release ventilation on intracranial pressure and oxygenation of patients with traumatic brain injuries 2015-07-23 anticipated 40 Complete https://irct.ir/trial/19793 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. N/A traumatic brain injuries. Intervention 1: Intervention of this research is a ventilation mode that is called Airway Pressure Release Ventilation that applied for half an hour. This is an inverse ratio mode that airway pressure of patient, between high pressure and low pressure is fluctuated. In this intervention, the duration of high pressure is 5 second and duration of low pressure is 1 second. The high-level pressure based on the mean airway pressure of patient. Intervention 2: In the control group patients are ventilated with SIMV mode for half an hour.