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IRCT2017030722206N3 IRCT 2017-05-01 Vice chancellor for research of Shiraz University of Medical Sciences The effect of Granulocyte Colony-Stimulating Factor (G-CSF) on endometrial thickness The effect of intrauterine infusion of Granulocyte Colony-Stimulating Factor (G-CSF) on endometrial thickness in frozen embryo transfer 2017-02-19 anticipated 80 Complete https://irct.ir/trial/19208 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Infertility and treatment methods. Intervention 1: Intervention group : intrauterine injection of 300 microgram Granulocyte colony-stimulating factor (G-CSF) in tenth day of hormone replacement therapy (HRT cycle). Intervention 2: Control group: not intrauterine injection of Granulocyte colony-stimulating factor (G-CSF), prescription of Estradiol valerate from second day of menstrual cycle and increasing dose (2 mg, every 4).
public Dr. Shima Talebi
Shiraz University of Medical Sciences, zand street
Shiraz Iran (Islamic Republic of) +98 71 3233 2365 stud2480307603@sums.ac.ir Shiraz University of Medical Sciences scientific Dr.Alamtaj Samsami
Shiraz University of Medical Science, Zand Street
Shiraz Iran (Islamic Republic of) +98 71 3233 2365 samsamia@sums.ac.irhafez_perina@sums.ac.ir Shiraz University of Medical Science Iran (Islamic Republic of) Inclusion criteria: Infertile women, Age between 20-45, women are receiving conventional treatment: estradiol valerate , women with normal endometrial thickness (more than 6 mm) for control group and women with endometrial thickness less than 6 mm for intervention group Exclusion criteria: Presence of Granulocyte colony, stimulating factor (G-CSF) contra-indications including: Sickle cell anemia, Chronic neutropenia, Past history of malignancy, Presence of malignancy, Upper respiratory infections, History of uterine surgery, Renal failure, Azoospermia in patient's husband, Pneumonia, Congenital fructose intolerance, Thyroid diseases , Diabetes, Asherman syndrome 20 years 45 years Female N97 Female infertility Treatment - Drugs Treatment - Drugs Intervention group : intrauterine injection of 300 microgram Granulocyte colony-stimulating factor (G-CSF) in tenth day of hormone replacement therapy (HRT cycle) Control group: not intrauterine injection of Granulocyte colony-stimulating factor (G-CSF), prescription of Estradiol valerate from second day of menstrual cycle and increasing dose (2 mg, every 4) Endometrial thickness. Timepoint: Before intervention and 72 hours after intervention. Method of measurement: Transvaginal sonography. Clinical pregnancy. Timepoint: 3 weeks after positive serum βhCG. Method of measurement: Vaginal ultrosonography. Implantation rate. Timepoint: 14 days after embryo transfer. Method of measurement: Measurement of serum βhCG. Vice chancellor for research of Shiraz University of Medical Sciences Approved 2016-05-09 Ethics committee of Shiraz University of Medical Sciences Shiraz University of Medical Sciences, Zand Street, Shiraz Shiraz Iran (Islamic Republic of)