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IRCT2016122722134N4 IRCT 2017-01-07 Vice Chancellor for research of Isfahan University of Medical Sciences Comparison in myocardial perfusion between the intracoronary versus intralesional eptifibatide administration in acute myocardial infarction Comparison in myocardial perfusion between the intracoronary versus intralesional eptifibatide administration during primary percutaneous coronary intervention in acute ST-segment elevation myocardial infarction; A randomized clinical trial 2016-05-22 anticipated 60 Complete https://irct.ir/trial/19170 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 cardiovascular disease. Intervention 1: In group I, before performing PCI, if caught thrombosis in (180 micrograms per kilogram) coronary arteries, patients received two boluses of eptifibatide through the guiding catheter in the infarct-related. Intervention 2: In group II or intralesional administration group boluses of eptifibatide(180 micrograms per kilogram) is administered through the export aspiration catheter into the lesion of infarct-related artery.
public Abdulattef Ghazal
Hezar Jerib Ave., Azadi sqr., Isfahan University of Medical Science, Isfahan, Iran
Isfahan Iran (Islamic Republic of) +98 31 3260 0961 dr.abdghazal@gmail.com Isfahan University of Medical Sciences scientific Dr. Hassan Shemirani
Hezar Jerib Ave., Azadi sqr., Isfahan University of Medical Science, Isfahan, Iran
Isfahan Iran (Islamic Republic of) +98 31 3260 0961 shemirani@med.mui.ac.ir Isfahan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Diagnosis of ST elevation myocardial infarction (STEMI) as defined by chest pain suggestive for myocardial ischemia for at least 30 minutes before hospital admission and symptoms onset time was less than 12 hours with 1 mm ST segment elevation in 2 or more contiguous leads (for V1-V3 ST elevation was 2 mm) simultaneously; These patients should also have three or more thrombus burden grade on the angiography. Thrombus burden was graded (G) as G0 = no thrombus, G1 = possible thrombus, G2 = small (greatest dimension ≤ 1/2 vessel diameter), G3 = moderate (> 1/2 but < 2 vessel diameter), G4 = large (≥ 2 vessel diameter), G5 = unable to assess TB due to vessel occlusion; undergoing PCI; The consent of patients or their families to participate in the study; insensitivity to Eptifibatide Exclusion criteria: Rescue PCI after thrombolytic therapy; Contraindications for antiplatelet such as bleeding disorder including gastrointestinal bleeding, hematuria, or known any bleeding tendency; thrombocytopenia (Platelet count<100.000/cm3); recent stroke (less than 6 months) and cardiogenic shock no limit no limit Both I20-I25 Certain current complications following acute myocardial infarction Treatment - Drugs Treatment - Drugs In group I, before performing PCI, if caught thrombosis in (180 micrograms per kilogram) coronary arteries, patients received two boluses of eptifibatide through the guiding catheter in the infarct-related In group II or intralesional administration group boluses of eptifibatide(180 micrograms per kilogram) is administered through the export aspiration catheter into the lesion of infarct-related artery Thrombolysis in myocardial infarction (TIMI) flow. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: TIMI flow grading. Myocardial blush grade (MBG). Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: Myocardial blush grading. No-reflow phenomenon. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: TIMI flow grading and Myocardial blush grading. Re myocardial infarction. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: ECG. Heart failure. Timepoint: during hospitalization. Method of measurement: Eco cardiography. Arrhythmia. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: ECG. Ventricular systolic function. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: Eco cardiography. Vice Chancellor for research of Isfahan University of Medical Sciences Approved 2016-05-18 Ethics committee of Isfahan University of Medical Sciences Hezar jirib St. Isfahan Iran (Islamic Republic of)