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IRCT2015050722134N1 IRCT 2015-06-16 Vice chancellor for research,Shahrekord University of Medical Sciences contrast-induced nephropathy and the patient’s undergone coronary angiography Comparison of N-acetylcysteine, Ascorbic acid and Normal saline effect in prevention of contrast-induced nephropathy on the patient’s undergone coronary angiography 2014-05-22 anticipated 120 Complete https://irct.ir/trial/19167 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2 Condition 1: Acute nephritic syndrome. Condition 2: Heart failure. Intervention 1: group A:N-acetylcysteine ( NAC)(600mg/BID) plus normal saline (100ml/hour).for 72hours. Intervention 2: group B: ascorbic acid (250 mg/BID) plus normal saline (100ml/hour). for 72 hours. Intervention 3: group C :normal saline (100ml/hour). for 72 hours. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593658/pdf/ARYA-11-228.pdf BACKGROUND: Considering the crucial role of appropriate preventative strategies in reducing<br /> the rate of contrast-induced nephropathy (CIN) occurrence and its related morbidity and<br /> mortality, the effect of N-acetylcysteine (NAC), ascorbic acid (AA), and normal saline (NS) was<br /> investigated in the patient’s undergone coronary angiography.<br /> METHODS: In this clinical trial, 120 patients scheduled for elective coronary angiography with serum<br /> creatinine (Cr) level > 1.5 mg/dl or glomerular filtration rate (GFR) ≥ 60 selected by convenience<br /> method. Selected patients were allocated in three treatment groups randomly to receive oral NAC<br /> (600 mg/twice daily) plus NS (100 ml/hour) (Group A), oral AA (250 mg/twice daily) plus NS (100<br /> ml/hour) (Group B) and NS (100 ml/hour) (Group C), respectively. The occurrence of CIN was<br /> evaluated based on serum Cr and GFR in three studied groups, before and after angiography<br /> procedure. The analysis of variance and paired t-test were used for data analysis by SPSS.<br /> RESULTS: The serum Cr increased and GFR decreased significantly during the intervention in three<br /> groups (P < 0.010). However, the amounts of these changes were equal between groups (P > 0.050).<br /> CONCLUSION: The study showed that nor the addition of NAC neither the addition of AA to<br /> sodium chloride infusion has more beneficial effect than hydration with sodium chloride, in the<br /> prevention of CIN. <br />
public Amrollah Ebrahimi
Isfahan University of Medical Sciences, Azadi Square, Harjirib Street,Isfahan
Isfahan Iran (Islamic Republic of) +98 913 117 1521 a_ev11@yahoo.com Isfahan University of Medical Sciences scientific Ali Momeni
Shahrekord University of Medical Sciences, Blvarayt Ayatollah Kashani, Staff University, Building No. 2, Vice chancellor for research,Shahrekord
Shahrekord Iran (Islamic Republic of) +98 38 3333 0061 dr.ali_momeny@yahoo.com Shahrekord university of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: creatinine level of >1.5mg/dl; glomerular filtration rate ( GFR) ≤ 60 Exclusion criteria: Oliguria (<400cc/24hours); severe heart failure with left ventricular ejection fraction (LVEF) < 35%; contrast-agent hypersensitivity; pregnancy; lactation; acute renal failure; Vitamin C supplements no limit no limit Both I50 Left ventricular failure Treatment - Drugs Treatment - Drugs Treatment - Drugs group A:N-acetylcysteine ( NAC)(600mg/BID) plus normal saline (100ml/hour).for 72hours group B: ascorbic acid (250 mg/BID) plus normal saline (100ml/hour). for 72 hours group C :normal saline (100ml/hour). for 72 hours Creatinine. Timepoint: before and after angiography. Method of measurement: ELISA kit. Glomerular filtration. Timepoint: before and after angiography. Method of measurement: Were used average estimated glomerular filtration rate of clearance of endogenous or exogenous materials. Vice chancellor for research,Shahrekord University of Medical Sciences Approved 2010-05-18 Ethics committee of Shahrekord University of Medical Sciences Shahrekord University of Medical Sciences, Blvarayt Ayatollah Kashani, Staff University, Building No. 2, Vice chancellor for research,Shahrekord Shahrekord Iran (Islamic Republic of)