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IRCT2015050622130N1 IRCT 2015-07-19 Isfahan University of Medical Sciences Effectiveness of splinting and local steroid injection in severe carpal tunnel syndrome Comparative assessment of splinting and splinting plus local steroid injection outcomes in severe carpal tunnel syndrome 2013-06-22 anticipated 56 Complete https://irct.ir/trial/19164 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A carpal tunnel syndrome. Intervention 1: One group (group A) is prescribed to use full time neutral wrist splint for 12 weeks. Intervention 2: In group B using sterilized method and a 25G needle, 40mg methylprednisolone acetate (Depomedrol) is injected to the wrist-flexon crease just ulnar to the palmaris longus tendon. The needle is introduced with a 30 ° angle. If the patient complains of pain and paresthesia in hand, the needle is withdrawn and re-positioned. Then patients are prescribed to use the full time neutral wrist splint during the study period for 12 weeks.
public Dr. Sayed Amir Ebrahim Mahmoodian
Isfahan University of Medical Sciences, Hezar Jarib Av.
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3668 8466 Dean@med.mui.ac.ir Isfahan University of Medical Sciences, Medical faculty scientific Dr. Sayed Amir Ebrahim Mahmoodian
Isfahan University of Medical Sciences, Hezar Jarib Av.
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3668 8466 Dean@med.mui.ac.ir Isfahan University of Medical Sciences, Medical faculty Iran (Islamic Republic of) Inclusion criteria: patients with signs and symptoms of CTS aged ≥18 years؛electrodiagnostic evidences of moderate to severe CTS. Exclusion criteria: Patients with secondary causes of CTS (diabetes mellitus؛ thyroid dysfunction؛ malignancy؛ distal radius fracture؛ pregnancy)؛ conditions affecting treatment outcomes (cervical disc herniation؛ fibromyalgia؛ coexisting neuropathy؛ previous steroid injection into the affected wrist)؛ patients with thenar muscles atrophy due to advanced CTS. no limit no limit Both G56.0 Carpal tunnel syndrome Treatment - Other Treatment - Drugs One group (group A) is prescribed to use full time neutral wrist splint for 12 weeks. In group B using sterilized method and a 25G needle, 40mg methylprednisolone acetate (Depomedrol) is injected to the wrist-flexon crease just ulnar to the palmaris longus tendon. The needle is introduced with a 30 ° angle. If the patient complains of pain and paresthesia in hand, the needle is withdrawn and re-positioned. Then patients are prescribed to use the full time neutral wrist splint during the study period for 12 weeks. Clinical and functional status. Timepoint: baseline, 4 weeks and 12 weeks later. Method of measurement: Boston Questionnaire. Electrodiagnostic findings. Timepoint: baseline and 12 weeks later. Method of measurement: electromyography instrument. Patients satisfaction. Timepoint: baseline, 4 weeks and 12 weeks later. Method of measurement: Likert scale. Local steroid injection complications. Timepoint: after injection,4 weeks and 12 weeks later. Method of measurement: patients complaints and physical examination. Isfahan University of Medical Sciences Approved 2013-05-01 Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar Jarib Av. Isfahan Iran (Islamic Republic of)