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IRCT2015042021875N1 IRCT 2016-09-18 Vice chancellor for research and technology of Islamic Azad University of Shahrood Comparison of efficacy of two ophthalmic drops on decreasing intraocular pressure Comparison of efficacy and side effects of Latanoprost versus Timolol on decreasing IOP in patients with glaucoma 2015-03-21 anticipated 40 Complete https://irct.ir/trial/19029 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Crossover, Purpose: Treatment. N/A Glaucoma. Intervention 1: Intervention group: Latanoprost ophthalmic drop 0.005% dripping one drop in each eye every night for 3 months. Intervention 2: Control group: Timolol ophthalmic drop 0.5% dripping one drop in each eye twice a day for 3 months.
public Negin Ebrahimi
Imam Hossein Hospital of Shahrood, Tohidi St, Imam Ave
Shahrood Iran (Islamic Republic of) +98 23 3234 2000 n.ebrahimi@iau-shahrood.ac.ir; gnaang2002@yahoo.com; neginiphone6p@gmail.com Imam Hossein Hospital of Shahrood scientific Dr Saeed Nushirvanpur
Imam Hossein Hospital of Shahrood, Tohidi St, Imam Ave
Shahrood Iran (Islamic Republic of) +98 23 3234 2000 SNushirvanpur@yahoo.com Imam Hossein Hospital of Shahrood Iran (Islamic Republic of) Inclusion criteria: Presence of open angle glaucoma symptoms; ocular hypertension includes patients with increased IOP; glaucomatous cupping (cup to disc ratio between 0.4 - 0.7; disc-cup asymmetry>0.2; notching of the rim; enlargement of the cup; bleeding of the rim of the disc; degeneration of the nerve fiber layer) Exclusion criteria: Secondary causes of increasing IOP; cup to disc ratio>0.7; IOP>30 mmHg in each stage of the disease; existing of any other ocular disorder except glaucoma; corrected vision less than 20/50; bradycardia; asthma; COPD; consumption of any drug affecting IOP for example beta blockers, corticosteroids, carbonic anhydrase inhibitors, nitrates and alpha 2 agonists; discontent of patient. 18 years 75 years Both H40, H40.0 Glaucoma, Glaucoma suspect Treatment - Drugs Treatment - Drugs Intervention group: Latanoprost ophthalmic drop 0.005% dripping one drop in each eye every night for 3 months. Control group: Timolol ophthalmic drop 0.5% dripping one drop in each eye twice a day for 3 months. Tonometry. Timepoint: Before intervention, if the first wash out period is needed every 2 weeks during 4 weeks, at the end of the first week, the first and third month, every 2 weeks during 4 weeks in the second wash out period and at the end of the first week, the first and third month after the second wash out period. Method of measurement: Applanation Haag-Streit tonometer. Refraction. Timepoint: Before intervention, at the end of the third month, at the end of the sixth month. Method of measurement: Refractor. Gonioscopy. Timepoint: Before intervention, at the end of the third month, at the end of the sixth month. Method of measurement: Slit lamp. Appointment of cup to disc ratio. Timepoint: Before intervention, at the end of the third month, at the end of the sixth month. Method of measurement: Slit lamp. Eye irritation. Timepoint: Before intervention, if the first wash out period is needed every 2 weeks during 4 weeks, at the end of the first week, the first and third month, every 2 weeks during 4 weeks in the second wash out period and at the end of the first week, the first and third month after the second wash out period. Method of measurement: Questionnaire and examination by slit lamp. Blurred vision. Timepoint: Before intervention, if the first wash out period is needed every 2 weeks during 4 weeks, at the end of the first week, the first and third month, every 2 weeks during 4 weeks in the second wash out period and at the end of the first week, the first and third month after the second wash out period. Method of measurement: Questionnaire and examination by slit lamp. Vice chancellor for research and technology of Islamic Azad University of Shahrood Approved 2015-04-08 Committee on medical ethics of Medical University of Shahrood Medical University of Shahrood, Haftom-e-tir Sq Shahrood Iran (Islamic Republic of)