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IRCT2015041521779N1 IRCT 2015-10-28 Vice Chancellor for Research of Jondi Shapour University Of Medical Sciences of Ahvaz The effect of adding pyridostigmine to second generation antipsychotic drugs on schizophrenia symptoms: A double blind randomised placebo controlled clinical trial The effect of adding pyridostigmine to second generation antipsychotic drugs on schizophrenia symptoms: A double blind randomised placebo controlled clinical trial 2015-06-01 anticipated 30 Complete https://irct.ir/trial/18989 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Schizophrenia. Intervention 1: Interventional group:this group that include 15 schizophrenic patients are selected quite rondom and treated with 2 generation antipsychotic drugs , pyridostigmine tablet 60 mg will add to main treatment daily for one month.It is worth mentioning that pyridostigmine is one of anticholinestrase drugs and one of common treatment of MYASTHENIA GRAVIS disease. At the begining and end of 4 weeks we check PANSS and BPRS for paitients. Intervention 2: In placebo group that include 15 schizophrenic patients are selected rondom and treated with 2 generation antipsychotic drugs, placebo tablet that is quite similar to pyridostigmine tablet will add to their main treatment for one months.At begining and end of 4 weeks , PANSS and BPRS scales will check for patients.
public Dr Pakseresht Syrous
Golestan Hospital, Golestan Street, Ahvaz, Khouzestan
Ahvaz Iran (Islamic Republic of) 6135874366 +98 61337430025 paks392003@yahoo.com Jondi Shapour University of Medical Sciences of Ahvaz scientific Dr Boostani Haatam
Jondi Shapour University of Medical Sciences of Ahvaz , Golestan Street , Ahvaz, Khouzestan
Ahvaz Iran (Islamic Republic of) 6135874366 +98 61337430025 boostani-h@yahoo.com Jondi Shapour University of Medical Sciences of Ahvaz Iran (Islamic Republic of) The main inclusion criteria is having schizophrenia disorder.inclusion criteria: The average age between 20 to 40 years and knowing persian language and having consent of participation in this research and having no brain organic disease and using no any anti depressants such as tricyclics drugs and donepezi drug. Exclusion criteria :demensia and severe organic disease and very old age and young age and other neurologic diseases that patients must use anticholinesterase drugs and use of tricyclic antidepressants and donepezil drug. 20 years 40 years Both f20 The schizophrenic disorders are characterized in general by fundamental and characteristic distortions of thinking and perception, and affects that are inappropriate or blunted. Clear consciousness and intellectual capacity are usually maintained although Treatment - Drugs Treatment - Drugs Interventional group:this group that include 15 schizophrenic patients are selected quite rondom and treated with 2 generation antipsychotic drugs , pyridostigmine tablet 60 mg will add to main treatment daily for one month.It is worth mentioning that pyridostigmine is one of anticholinestrase drugs and one of common treatment of MYASTHENIA GRAVIS disease. At the begining and end of 4 weeks we check PANSS and BPRS for paitients. In placebo group that include 15 schizophrenic patients are selected rondom and treated with 2 generation antipsychotic drugs, placebo tablet that is quite similar to pyridostigmine tablet will add to their main treatment for one months.At begining and end of 4 weeks , PANSS and BPRS scales will check for patients. Schizophrenic Disorder Symptom. Timepoint: In First And End Of 4 Weeks Of Research. Method of measurement: By Using Panss And Bprs Scales. Comparsion between complications of adding pyridostigmine with 2 generation antipsycotic drugs versus complications of antipsychotics alone. Timepoint: Along of research. Method of measurement: With recurrent visit of patients. Vice Chancellor for Research of Jondi Shapour University Of Medical Sciences of Ahvaz Approved 2015-01-31 Ethics Committy of Jondi Shapour University of Medical Sciences of Ahvaz Golestan Street، Ahvaz ، Khouzestan Ahvaz Iran (Islamic Republic of)