<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT2015102121543N2</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2016-01-25</date_registration>
      <primary_sponsor>Ministry Of Higher Education, Malaysia</primary_sponsor>
      <public_title>The effects of exercise intervention on tobacco withdrawal symptoms (TWS) in smokers</public_title>
      <acronym></acronym>
      <scientific_title>The effects of exercise intervention on tobacco withdrawal symptoms in smokers</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2016-01-01</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>80</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/18854</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: quasi experimental.</study_design>
      <phase>1</phase>
      <hc_freetext>smoker and sedentary.</hc_freetext>
      <i_freetext>Intervention 1: Intervention  group is  an exercise training , 3 times per week, for 2 month running on treadmill with moderate intensity (64-77% HR max) and  need to maintain smoking habit. Intervention 2: control group no exercise but need to maintain their  sedentary lifestyle  and smoking habit.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan></results_IPD_plan>
      <results_IPD_description></results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Siti Munira Yasin</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Jalan Hospital</address>
        <city>SG BULOH</city>
        <country1>Malaysia</country1>
        <zip>47000</zip>
        <telephone>001761267737</telephone>
        <email>smunira@salam.uitm.edu.my</email>
        <affiliation>Universiti Teknologi MARA, Sg Buloh</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Nur- Hasanah Ruslan</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>No. 2020, Pondok Gaal</address>
        <city>Pasir Puteh</city>
        <country1>Malaysia</country1>
        <zip>16800</zip>
        <telephone>00179075770</telephone>
        <email>nur_hasanahruslan@yahoo.com</email>
        <affiliation>Universiti Teknologi MARA, Sg Buloh</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Malaysia</country2>
      <country2>Malaysia</country2>
    </countries>
    <criteria>
      <inclusion_criteria>inclusions criteria&#13;
Male smokers;who smoke at least 10 cigarettes per day at least for the past  2 years; who have sedentary lifestyle is determining by use of IPAQ (International Physical Activity Questionnaire) ;aged between 20-45 year old;categorized as low and moderate risks by ACSM recommendations identified by AHA/ACSM ; Preparticipation Screening   Questionnaires;who are in the pre-contemplation stage ; who are systolic blood  pressure  around 90-140 mmHg and  diastolic around 60-90mmHg; who are body mass index (BMI) less than 30 kg/m2; who are fasting blood cholesterol not more than 200 mg/dl; who are fasting  blood glucose not more than 100mg/dL and who  are willing to comply with the study’s protocol &#13;
&#13;
Exclusion&#13;
who smoke more than  20 cigarette; who are categorized as high risk by ACSM recommendation ;who have cardiovascular diseases ;who have psychiatry problems or on medication; who face psychotherapy or pharmacotherapy for smoking cessation ; who  are depressed ; who  are hallucinogens /drug/opioid dependent for the past 6 months; who  are on a treatment of anxiety/mood disorder ;  who  have hypertension  ≥140 systolic blood pressure  and   ≥90 diastolic blood pressure; who  are fasting blood    cholesterol level ≥200mg/dl or medical  treatment with lipid abnormalities; who  are obese (≥30kg/m2);  who have orthopaedic problem ;who take alcohol</inclusion_criteria>
      <agemin>20 years</agemin>
      <agemax>45 years</agemax>
      <gender>Male</gender>
      <exclusion_criteria></exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code></hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword></hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Lifestyle</i_code>
      <i_code>N/A</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>Intervention  group is  an exercise training , 3 times per week, for 2 month running on treadmill with moderate intensity (64-77% HR max) and  need to maintain smoking habit</i_keyword>
      <i_keyword>control group no exercise but need to maintain their  sedentary lifestyle  and smoking habit</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Tobacco withdrawal symptoms. Timepoint: before training, after 2 month training and after 2 weeks of detraining in 12 hours of overnight abstinent. Method of measurement: using  Wiscounsin Scale withdrawal symptom  (WSWS)questionnaire.</prim_outcome>
      <prim_outcome>Irritability. Timepoint: before training, after 2 month training and after 2 weeks of detraining in 12 hours of overnight abstinent. Method of measurement: blood pressure and temperature.</prim_outcome>
      <prim_outcome>Quality of sleep. Timepoint: before training, after 2 month training and after 2 weeks of detraining in 12 hours of overnight abstinent. Method of measurement: Pittsburgh Sleep Quality index (PSQI).</prim_outcome>
      <prim_outcome>Smoking urge. Timepoint: before training, after 2 month training and after 2 weeks of detraining in 12 hours of overnight abstinent. Method of measurement: question of smoking urge (brief  QSU).</prim_outcome>
      <prim_outcome>Mood. Timepoint: before training, after 2 month training and after 2 weeks of detraining in 12 hours of overnight abstinent. Method of measurement: profile mood state (POMS).</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome>Cortisol, adrenalin and beta endorphin. Timepoint: before training, after training and after 2 weeks of detraining. Method of measurement: blood.</sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Ministry Of Higher Education, Malaysia</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2015-12-22</approval_date>
        <contact_name>Universiti Teknologi MARA</contact_name>
        <contact_address>Universiti Teknologi MARA (UiTM) Shah Alam Shah Alam Selangor Malaysia</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
