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IRCT2015031621494N1 IRCT 2015-07-17 Vice Chancellor for Research and Technology of Babol University of Medical Sciences A histologic, histomorphometric and radiographic comparison between two complex of Cenobone/ Cenomembrane and Bio Oss/ Bio Gide in lateral ridge augmentation: a preliminary study. A histologic, histomorphometric and radiographic comparison between two complex of Cenobone/ Cenomembrane and Bio Oss/ Bio Gide in lateral ridge augmentation: a preliminary study. 2014-06-22 anticipated Complete https://irct.ir/trial/18831 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 4 Lateral alveolar ridge augmentation. Intervention 1: Intervention group: Cenobone/ Cenomembrane. In this group, Cenobone granules with size of 150 to 1000 microns (Mineralized Cortico Cancellous powder) which have been immersed in normal saline for 30 minutes, are placed in the defected area of bone in such a manner that provide sufficient bone thickness for implant placement in buccal and lingual sides of the ridge. Consequently, absorbable Cenomembrane with thickness of 0.2 to 0.6 microns which originates from allogenic pericardium, is placed over the graft materials. Both bone powder and absorbable membrane are products of Hamanandsaz Baft Kish, Iran. Intervention 2: Intervention group:Bio Oss/ Bio Gide. In this group, Bio Oss granules with size of 500 to 1000 microns which have been immersed in normal saline for 30 minutes, are placed in the defected area of bone in such a manner that provide sufficient bone thickness for implant placement in buccal and lingual sides of the ridge. Consequently, absorbable Bio Gide membrane with standard thickness which originates from pig collagen, is placed over the graft materials. Both bone powder and absorbable membrane are products of Geistlich Biomaterials (Bio Oss, Geistlich Pharma AG, Wolhusen, Switzerland).
public Dr Seyed Mohammad Ali Tabatabaei
Department of periodontology, Faculty of Dentistry, Babol University of Medical Sciences, Ganj Afrooz St., Babol
Babol Iran (Islamic Republic of) 47176- 47745 +98 11 3229 1408 ma.tabatabaei@mubabol.ac.ir Babol University of Medical Sciences scientific Dr Babak Amoeian
Department of periodontology, Faculty of Dentistry, Babol University of Medical Sciences, Ganj Afrooz St., Babol
Babol Iran (Islamic Republic of) 47176- 47745 +98 11 3219 9592 amoian@yahoo.com Babol University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Subjects within the age range of 30 to 50 years, and with sufficient alveolar bone height who have alveolar ridge width of 2 to 4 mm in the area at a distance of 3 mm from the ridge crest are included in the study. Exclusion criteria: Patients with certain systemic conditions which affect healing process are excluded from the survey, including: Uncontrolled diabetes; immune disorders; alcohol addiction; drug abuse; current smoking; pregnancy; immune suppressor or anticoagulant drugs consumption. Additionally, patients with poor compliance; sufferers from active periodontal diseases which complicate oral hygiene; and subjects who don't want to participate in the study are excluded. 30 years 50 years Both k08.2 Atrophy of edentulous ridge Treatment - Surgery Treatment - Surgery Intervention group: Cenobone/ Cenomembrane. In this group, Cenobone granules with size of 150 to 1000 microns (Mineralized Cortico Cancellous powder) which have been immersed in normal saline for 30 minutes, are placed in the defected area of bone in such a manner that provide sufficient bone thickness for implant placement in buccal and lingual sides of the ridge. Consequently, absorbable Cenomembrane with thickness of 0.2 to 0.6 microns which originates from allogenic pericardium, is placed over the graft materials. Both bone powder and absorbable membrane are products of Hamanandsaz Baft Kish, Iran. Intervention group:Bio Oss/ Bio Gide. In this group, Bio Oss granules with size of 500 to 1000 microns which have been immersed in normal saline for 30 minutes, are placed in the defected area of bone in such a manner that provide sufficient bone thickness for implant placement in buccal and lingual sides of the ridge. Consequently, absorbable Bio Gide membrane with standard thickness which originates from pig collagen, is placed over the graft materials. Both bone powder and absorbable membrane are products of Geistlich Biomaterials (Bio Oss, Geistlich Pharma AG, Wolhusen, Switzerland). Lateral ridge augmentation. Timepoint: Six months following grafting. Method of measurement: Radiographic, histologic, and histomorphometric measures. Trabecular thickness. Timepoint: Six months following grafting. Method of measurement: Histomorphometric evaluation six months following grafting. Number of blood vessels. Timepoint: Six months following grafting. Method of measurement: Evaluation in microscopic fields, six months following grafting. Extent of inflammation. Timepoint: Six months following grafting. Method of measurement: Evaluation in microscopic fields, six months following grafting. Foreign body reaction. Timepoint: Six months following grafting. Method of measurement: Evaluation in microscopic fields, six months following grafting. Bone vitality. Timepoint: Six months following grafting. Method of measurement: Evaluation in microscopic fields, six months following grafting. Biomaterial/bone contact. Timepoint: Six months following grafting. Method of measurement: Evaluation in microscopic fields, six months following grafting. Biomaterial/bone radiographic density. Timepoint: Six months following grafting. Method of measurement: CBCT examination, six months following grafting. Percentage of biomaterial remnants. Timepoint: Six months following grafting. Method of measurement: Histomorphometric evaluation six months following grafting. Vice Chancellor for Research and Technology of Babol University of Medical Sciences Approved 2015-02-07 Ethics committee of Babol University of Medical Sciences Ethics committee, Babol University of Medical Sciences, Ganj Afrooz St., Babol. Babol Iran (Islamic Republic of)