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IRCT2015022821273N1 IRCT 2015-04-04 Yazd University of Medical Science Effect of the brain stimulation with very weak electrical current in opiod addiction tDCS-UROD Transcranial direct current stimulation effects on the treatment of the opiate addiction in Ultra rapid opioid detoxification method 2015-03-08 anticipated 40 Complete https://irct.ir/trial/18677 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A opiod addiction. Intervention 1: intervention group:We will apply real mode of tDCS once a day for three successive sessions. anodal electrode will locate on the right dorsolateral prefrontal cortex(DLPFC) and cathode on the left one. The intensity of electrical current is 2mA for 20 minutes through each session. Direct current will be transferred by using a saline-soaked pair of surface sponge. Intervention 2: control group:We will apply sham mode of tDCS once a day for three successive sessions. anodal electrode will locate on the right dorsolateral prefrontal cortex(DLPFC) and cathode on the left one.Since the study is double blind,device will remain for20 minutes. The intensity of electrical current is 2mA for 30 seconds through each session and then the device will be put out. Direct current will be transferred by using a saline-soaked pair of surface sponge.
public Hamid Mirhosseini
Anesthesia department, Paramedical institue, Imam Hossein square, Yazd
Yazd Iran (Islamic Republic of) 8916188635 +98 35 3624 5956 mirhosseini@tabrizu.ac.ir mirhoseini.h@gmail.com Yazd University of Medical Sciences scientific Hamid Mirhosseini
Anesthesia department, Paramedical institue, Imam Hossein square, Yazd
Yazd Iran (Islamic Republic of) 8916188635 +98 35 3624 5956 mirhosseini@tabrizu.ac.ir mirhoseini.h@gmail.com Yazd Medical science University Iran (Islamic Republic of) Inclusion criteria:Diagnostic criteria for opiate dependence defined by Diagnostic and Statistical Manual of Mental Disorders (4th ed.) (DSM-IV); Inhalational application route;Literate; last usage at the night before;male gender Exclusion criteria: Siezure or any history of convulsion which has been prohibited for tDCS;Cardiopulmomary or Hepatic diease or any sensitivity to anesthetics which have been prohibited for general anesthesia; Comorbidy of other psychiatric disorders such as psychosis,anxiety,mood and affective disorder;Amphetamine,Alcohol and sedatives abuse no limit no limit Male Z71.5 Drug abuse counselling and surveillance Treatment - Devices Treatment - Devices intervention group:We will apply real mode of tDCS once a day for three successive sessions. anodal electrode will locate on the right dorsolateral prefrontal cortex(DLPFC) and cathode on the left one. The intensity of electrical current is 2mA for 20 minutes through each session. Direct current will be transferred by using a saline-soaked pair of surface sponge control group:We will apply sham mode of tDCS once a day for three successive sessions. anodal electrode will locate on the right dorsolateral prefrontal cortex(DLPFC) and cathode on the left one.Since the study is double blind,device will remain for20 minutes. The intensity of electrical current is 2mA for 30 seconds through each session and then the device will be put out. Direct current will be transferred by using a saline-soaked pair of surface sponge Craving. Timepoint: before,afte rand 1,3,12hrs and 2weeks,1,3months after treatment. Method of measurement: DDQ questionary. Withdrawal syndrom. Timepoint: before,afte rand 1,3,12hrs and 2weeks,1,3months after treatment. Method of measurement: OOWS questionary. Relapse. Timepoint: 2 weeks,1 & 3 months after treatment. Method of measurement: Interviews & Urine strip test. Irritation of electrode location. Timepoint: after the last intervention. Method of measurement: observation. Yazd University of Medical Science Approved 2014-06-02 Yazd University of medical science Headquarters of University, Bahonar square, Yazd Yazd Iran (Islamic Republic of)