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IRCT201408191138N12 IRCT 2014-09-17 Guilan University of Medical Sciences,Vice Chancellor for Research aspirin hypersensitivity ENT-HNS comparison of frequency of aspirin hypersensitivity in people with and without nasal polyps 2014-09-23 anticipated 96 Complete https://irct.ir/trial/185 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Diagnostic. N/A Nasal polyp. In both group oral aspirin challenge test is done. On the first day,aspirin with exponentially increasing doses (20,40,80mg),are administered at 3-hour intervals and On the second day,aspirin with exponentially increasing doses (120,160,325mg),are administered at 3-hour intervals..
public Dr Shadman Nemati
Amiralmomenin Hospital,17 shahrivar st
Rasht Iran (Islamic Republic of) 4139637459 +98 13 1222 5242 nemati@gums.ac.ir Guilan University of Medical Sciences scientific Dr Shadman Nemati
Amiralmomenin Hospital,17 shahrivar st.
Rasht Iran (Islamic Republic of) 4139637459 +98 13 1222 5242 nemati@gums.ac.ir Guilan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria:All patients with nasal polyps that including male and female and in range of 18-60 years old who referred to ENT service in Rasht, Amiralmomenin hospital and diagnosis of nasal polyps is definite for them by endoscopy or CTs if don't have contraindications for oral aspirin challenge test inclusion to our study. Those with contraindications for oral aspirin challenge test were left out of the study : 1-a history of very severe anaphylactic reaction, 2-severe disease of the heart, digestive tract, liver and kidney, 3- infection of respiratory tract within 4weeks prior to the challenges, 4- pregnancy, 5- current treatment with beta receptor blocker. Control group is healthy people that don't have nasal polyps and contraindications for oral aspirin challenge test. Exclusion criteria:If the result of test is positive. 18 years 60 years Both J33 Nasal polyp Diagnosis In both group oral aspirin challenge test is done. On the first day,aspirin with exponentially increasing doses (20,40,80mg),are administered at 3-hour intervals and On the second day,aspirin with exponentially increasing doses (120,160,325mg),are administered at 3-hour intervals. Nasoocular symptoms alone. Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection. Nasoocular symptoms and a 15% or greater decline in FEV(classic reaction). Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam. Lower respiratory reaction only (FEV1 declines by >20%). Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam. Laryngospasm with or without any of the first 3 reactions. Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam. Systemic reactions: hives, flushing, gastric pain, hypotension. Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam. Guilan University of Medical Sciences,Vice Chancellor for Research Approved 2014-05-02 Guilan University of medical sciences Shahid Beheshti BL. Rasht Iran (Islamic Republic of)