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IRCT2016022220592N4 IRCT 2016-06-21 Shahid Beheshti University of Medical Sciences A comparison of therapeutic effects of teicoplanin versus vancomycin in patients admitted to the Intensive Care Unit after cardiac surgery A comparison of therapeutic effects of teicoplanin versus vancomycin in patients admitted to the Intensive Care Unit after cardiac surgery because of MRSA infectious endocarditis in Masih Daneshvari hospital between years 2012-2016 2012-08-30 anticipated 46 Complete https://irct.ir/trial/18239 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Endocarditis. Intervention 1: Intenvention : Teicoplanin, Teicoplanin was used by intravenous and intramuscular injection and single dose daily. Intervention 2: Control: Vancomycin, Initial Vancomycin dose was 1500 mg every 12 hours until serum concentration monitoring indicates the need for higher dosing.
public Seyed Mohammad reza Hashemian
Masih Daneshvari Hospital, Darabad, Niavaran Sq, Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 2610 9512 smrhashemian@sbmu.ac.ir Masih Daneshvari Hospital scientific Seyed Mohammad reza hashemian
Masih Daneshvari Hospital, Darabad, Niavaran Sq, Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 2610 9512 smrhashemian@sbmu.ac.ir Masih Daneshvari Hospital Iran (Islamic Republic of) Exclusion criteria: Prohibition of use for each of the two drugs Inclusion Criteria: Surgery complications in invective endocarditis caused by organisms no limit no limit Both I33.9 Acute endocarditis, unspecified Treatment - Drugs Treatment - Drugs Intenvention : Teicoplanin, Teicoplanin was used by intravenous and intramuscular injection and single dose daily. Control: Vancomycin, Initial Vancomycin dose was 1500 mg every 12 hours until serum concentration monitoring indicates the need for higher dosing. Culture and isolation. Timepoint: at the start of the study and after 2 months. Method of measurement: observation. Shahid Beheshti University of Medical Sciences Approved 2014-09-23 Ethics Committee of Shahid Beheshti University of Medical Sciences Yemen Street, Shahid Chamran Highway, Shahid Beheshti University of Medical Sciences, Tehran, Iran Tehran Iran (Islamic Republic of)