IRCT2014123020485N1 IRCT 2015-05-25 Ahvaz Jundishapour Medical University Evaluation of efficacy of prophylactic antibiotic therapy in prevention of incidence of meningitis in patient with basilar skull fracture and cerebrospinal fluid leakage Evaluation of efficacy of prophylactic antibiotic therapy in prevention of incidence of meningitis in patient with basilar skull fracture and cerebrospinal fluid leakage in traumatic patient reffer to golestan hospital of ahvaz in 2014-2015 2015-02-08 anticipated 346 Complete https://irct.ir/trial/18164 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. N/A Fracture of base of skull due to trauma. Intervention 1: Approximately 178 patients with CSF leak following base skull fractures were selected. For prophylaxis, two Cotrimoxazole tablets (400/80 miligram) and three Amoxicillin capsules (500 miligram) were administered daily. Intervention 2: In the control group, placebo drugs with complete resemblance to the actual drugs were given to patients (two Cotrimoxazole placebo tablets and three Amoxicillin placebo capsules, daily). The placebo drugs were provided by Ahvaz Jundishapour Medical Universities School of Pharmacy.