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IRCT2014121920366N1 IRCT 2015-02-14 Vice chancellor for research,Isfahan University of Medical Science The Effects of Portulaca oleracea Extract capsule on inflammatory biomarkers, lipid profile and serum glucose, anthropometric indices and blood pressure The Effects of Portulaca oleracea Extract capsule on inflammatory biomarkers, lipid profile and serum glucose, anthropometric indices and blood pressure in adult with Metabolic syndrome for prevention of heart disease. 2014-04-06 anticipated 40 Complete https://irct.ir/trial/18064 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: Making Purslane extract capsule: Purslane Confirmed in the Department of Pharmacognosy , Faculty of Pharmacy, then, 20 kg of plants dried in the shade , with 150 liters of ethanol with maceration method for 4 days extraction was repeated three times. The extract was filtered through filter paper using a rotary evaporator ( Haydolf , Germany ) under the pressure of a vacuum pump with a pressure of 10 mbar and a temperature of 40 ° C Was solved. The concentrated extract mixtured with anhydrous calcium phosphate powder (di calcium phosphate), and then through a sieve size 20 (850/0 mm) was granulated and dried at 40 ° C. The dried granules were sifting with sieve size 20 again. Finally purslane capsules were made granules containing dried extract of Portulaca oleracea extract as much as 500 mg per capsule at the Isfahan School Pharmacy. 1 Metabolic syndrome. Intervention 1: intervention group consume Purslane extract capsules. Two capsules 500 mg , one 30 minutes before breakfast and another 30 minutes before dinner. Intervention 2: control group consume placebo capsule for 2 months. 1 capsule 30 minutes before breakfast and 1 capsule 30 minutes before dinner. Placebo was made ​​of calcium phosphate.
public Marjan Badakhanian
Department Of Clinical Nutrition, School Of Nutrition and Food Sciences, Isfahan University Of Medical Sciences, Hezar Jerib Street, Isfahan
Isfahan Iran (Islamic Republic of) +98 31 3792 2752 marjanbadakhanian@ymail.com Isfahan University of Medical Sciences scientific Marjan Badakhanian
Department Of Clinical Nutrition, School Of Nutrition and Food Sciences, Isfahan University Of Medical Sciences, Hezar Jerib Street, Isfahan
Isfahan Iran (Islamic Republic of) +98 31 3792 2752 marjanbadakhanian@ymail.com Isfahan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: persons suffering from obesity as defined by the IDF (WC≥ 102 in men) and have 2 signs of the 4 following symptoms, the metabolic syndrome was diagnosed. In this study, the characteristics of metabolic syndrome will be considered, if the criteria were the terms of this syndrome (having 2 of the first 4), other criteria will be checked: 1-high blood pressure (systolic>130mhg and diastolic>85mmhg); 2-fasting blood glucose>100mg/dl; 3-TG>150mg/dl; 4-HDL<40mg/dl; -gender: male; no history of cancer, kidney, thyroid, diabetes, and anemia; lack of use of alcohol and drugs; no smoking history or drug allergy; no special diet; no change in medication in the last three months; lack of drugs that control blood sugar, lipid and blood pressure; no taking medications affecting inflammation, such as corticosteroids. Exclusion criteria: during the study , patients who lose their inclusion criteria, including smoking; suffering from diseases such as heart problems , kidney , thyroid and digestive disorders and lack of cooperation. 27 years 59 years Male E66.9 Obesity, unspecified Treatment - Drugs Placebo intervention group consume Purslane extract capsules. Two capsules 500 mg , one 30 minutes before breakfast and another 30 minutes before dinner. control group consume placebo capsule for 2 months. 1 capsule 30 minutes before breakfast and 1 capsule 30 minutes before dinner. Placebo was made ​​of calcium phosphate Serum high sensitive-C Reactive Protein (hs-CRP) levels. Timepoint: In the first of intervention and end of 8th week. Method of measurement: mg/l-imonotorbidometry. NON-HDL CHOL. Timepoint: In the first of intervention and end of 8th week. Method of measurement: Calculation method. Waist circumference. Timepoint: In the first of intervention and end of 8th week. Method of measurement: meter, centimeter. Weight. Timepoint: In the first of intervention and end of 8th week. Method of measurement: scale, kilogram. Body mass index. Timepoint: In the first of intervention and end of 8th week. Method of measurement: kg/m2, Weight/Height square. Diastolic blood pressure. Timepoint: In the first of intervention and end of 8th week. Method of measurement: mmHg, Mercurial sphygmomanometer. Systolic blood pressure. Timepoint: In the first of intervention and end of 8th week. Method of measurement: mmHg, Mercurial sphygmomanometer. Fasting blood sugar. Timepoint: In the first of intervention and end of 8th week. Method of measurement: Enzymatic, mg/dL. Serum total cholesterol levels. Timepoint: In the first of intervention and end of 8th week. Method of measurement: Enzymatic, mg/dL. Serum High-Density Lipoprotein cholesterol (HDL-c) levels. Timepoint: In the first of intervention and end of 8th week. Method of measurement: Enzymatic, mg/dL. Serum Low-Density Lipoprotein cholesterol (LDL-c) levels. Timepoint: In the first of intervention and end of 8th week. Method of measurement: Calculation method. Fibrinogen. Timepoint: In the first of intervention and end of 8th week. Method of measurement: Clauss method. Isfahan University of Medical Sciences, School of Nutrition- School Nutrition Research Center Vice chancellor for research,Isfahan University of Medical Science Isfahan University of Medical Sciences, School of Nutrition- School Nutrition Research Center Approved 2013-10-28 Ethical Committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar Jerib Avenue Isfahan Iran (Islamic Republic of)