IRCT2017020520351N9 IRCT 2017-02-21 Vice Chancellor for Research, Tehran University of Medical Sciences Evaluation of the effect of pretreatment of E2 and OCP in Antagonist cycle In IVF cycles. OCP; E2; Antagonist Evaluation of the effect of pretreatment of E2 and OCP before Antagonist cycle on IVF outcome. 2017-02-19 anticipated 195 Complete https://irct.ir/trial/18052 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2 Female infertility associated with anovulation. Intervention 1: In group without intervention ( Control): only antagonist 25 miligram daily is administrated from the second day of the cycle. In all three groups of patients after 6 days of treatment, vaginal ultrasound will be done every other day. When the follicles greater than 13 mm was observed, antagonist starts with 25 mg and when there is at least three follicles greater than 17 mm, HCG 10000 unit is injected. After 36 hours, pick up the ovum will be done. Intervention 2: In intervention group 1: daily treatment is a pill (OCP) for 10 days and 10-12 days before the last cycle. In all three groups of patients after 6 days of treatment, vaginal ultrasound will be done every other day. When the follicles greater than 13 mm was observed, antagonist starts with 25 mg and when there is at least three follicles greater than 17 mm, HCG 10000 unit is injected. After 36 hours, pick up the ovum will be done. Intervention 3: In intervention group 2: daily treatment is a Estradiol Pill for 10 days and before the start of Antagonist administration. In all three groups of patients after 6 days of treatment, vaginal ultrasound will be done every other day. When the follicles greater than 13 mm was observed, antagonist starts with 25 mg and when there is at least three follicles greater than 17 mm, HCG 10000 unit is injected. After 36 hours, pick up the ovum will be done.