IRCT2015061520250N1 IRCT 2015-11-17 Vice chancellor of Research and Technology,Tehran University of Medical Sciences and Health Services Diphencyprone effect on alopecia areata of eyebrow Evaluation of efficacy and safety of diphencyprone treatment on alopecia areata of eyebrows of patients referred to Tehran Razi hospital`s diphencyprone clinics in year 1394 2015-11-09 anticipated 40 Complete https://irct.ir/trial/17925 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Alopecia areata. Intervention 1: The intervention in this study is topical application of diphencyprone solution on eyebrow by patients. Solution dosage will be determined by a dermatologist. Treatment will be started at 0.0001%-0.001% concentration and after serial examination and history taking it will be increased biweekly as follows: 0.01%, 0.1%, 0.2%, 0.5%, 1% and 2%. The solution will be applied weekly on one eyebrow for six months. Intervention is unilateral for randomly selected side and the other side would be the control. After terminal hair regrowth application would be bilateral. Before and at third and sixth months of treatment, photography of eyebrows would be performed. Different concentrations that mentioned above will be made of diphencyprone powder (product of Sigma Aldrich Company) in acetone base at Razi hospital`s synthetic drugs ward. Intervention 2: No intervention.