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IRCT2014120820239N1 IRCT 2015-01-02 University Malaya Research Grant (UMRG) Sugar control following different exercises in diabetic patients with heart disease CADEX Study Effects of continuous aerobic training, high intensity interval training (HIIT) and combined aerobic with resistance training on glycated haemoglobin (HbA1c) in Type 2 Diabetes Mellitus patients with coronary artery disease 2012-06-01 anticipated 42 Complete https://irct.ir/trial/17920 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Other design features: This is a randomized prospective trial. Randomization is done using the Peto et al method. 2-3 type 2 diabetes mellitus with coronary artery disease. Intervention 1: Continuous aerobic training: 30 minutes walking on a treadmill and 30 minutes of cycling on an upright bike with moderate intensity (50-70% VO2max). Total training duration of 60 minutes. Intervention 2: High intensity interval training (HIIT): Subjects will train on cycling ergometer which last for 10 minute duration. They will start with gradual incremental intensity training for 6 minutes (maximum intensity 60-70% VO2max) then low intensity for another 4 minutes as their warm up session. Then the HIIT session consisted of 10 minutes exercise with every 60 seconds between low intensity and high intensity alternately. The cycle ergometer is set with resistance 40% VO2max for low intensity and 60-70% VO2max for high intensity. During the 60 second high intensity session, patients are to force and encourage to increase their cycle repetition per minute to maximum with the target in achieving Borg score of 17 and above. They were monitored and supervised during the 20 minute session. Intervention 3: Combined aerobic with resistance training: Continuous 30 minutes walking on a treadmill and 30 minutes of cycling on an upright bike at moderate intensity (50-70% VO2max). Then they have to do resistance training such as chest press, latissimus dorsi pull, leg press, leg extension or leg curl, abdominal muscle crunch and back extension. Total training duration is about 90 minutes.
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5th floor Menara Selatan
Petaling Jaya Malaysia 59100 006379498122 moriffin@gmail.com University Malaya Medical Centre Malaysia Patients who fulfill the inclusion and exclusion criteria as listed below are recruited: Inclusion criteria for the subjects are patients with type 2 diabetes mellitus with coronary artery disease co-morbidity manifested by one or more of these: -Ischemic Heart Disease, but no current angina -Post angioplasty / stenting or post coronary artery bypass surgery -Stable pharmacological therapy -Chronic Heart Failure New York Association (NYHA I, II and III) in the absence of congestive heart failure at the time of study Patients with the listed criteria are excluded from the study: -Myocardial Infarction, Cardiac arrest, symptomatic or sustained ventricular tachycardia in the previous 6 months -Unstable heart failure, or NYHA Class IV patients -Symptomatic or sustained ventricular tachycardia -Current angina or baseline assessment suggesting unsatisfactory control of heart failure -Current acute musculoskeletal event and/or neurological impairments that adversely affect exercise capacity. -Any other symptoms that prevent the patients from exercising. 36 years 74 years Both E11 non insulin dependent diabetes mellitus Lifestyle Lifestyle Lifestyle Continuous aerobic training: 30 minutes walking on a treadmill and 30 minutes of cycling on an upright bike with moderate intensity (50-70% VO2max). Total training duration of 60 minutes. High intensity interval training (HIIT): Subjects will train on cycling ergometer which last for 10 minute duration. They will start with gradual incremental intensity training for 6 minutes (maximum intensity 60-70% VO2max) then low intensity for another 4 minutes as their warm up session. Then the HIIT session consisted of 10 minutes exercise with every 60 seconds between low intensity and high intensity alternately. The cycle ergometer is set with resistance 40% VO2max for low intensity and 60-70% VO2max for high intensity. During the 60 second high intensity session, patients are to force and encourage to increase their cycle repetition per minute to maximum with the target in achieving Borg score of 17 and above. They were monitored and supervised during the 20 minute session. Combined aerobic with resistance training: Continuous 30 minutes walking on a treadmill and 30 minutes of cycling on an upright bike at moderate intensity (50-70% VO2max). Then they have to do resistance training such as chest press, latissimus dorsi pull, leg press, leg extension or leg curl, abdominal muscle crunch and back extension. Total training duration is about 90 minutes HbA1c (glycated haemoglobin). Timepoint: 12 weeks following end of treatment. Method of measurement: Blood sample laboratory test. Body composition. Timepoint: 12 weeks following end of treatment. Method of measurement: bioelectrical impedance analysis machine. Lipid profile. Timepoint: 12 weeks following end of treatment. Method of measurement: Blood sample laboratory test. Fasting blood glucose. Timepoint: 12 weeks following end of treatment. Method of measurement: Blood sample laboratory test. Maximum oxygen consumption (VO2max). Timepoint: 12 weeks following end of treatment. Method of measurement: cycling ergometer using Astrand or Naughton protocol. University Malaya Research Grant (UMRG) Approved 2011-10-19 Medical Ethics Committee University Malaya Medical Centre Lembah Pantai Kuala Lumpur Malaysia