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IRCT2016020420004N3 IRCT 2016-02-23 Vice challenger of research,Islamic Azad Dental University of Tehran Evaluation of Pro root-MTA and Retro root-MTA in partial pulpotomy of human dental healthy pulp Clinical, radiological and histological evaluation of Pro root-MTA and Retro root-MTA in partial pulpotomy of human dental healthy pulp 2015-09-01 anticipated 26 Complete https://irct.ir/trial/17757 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. 2 Vital pulp therapy. Intervention 1: Before the operative protocol, each tooth will be radiologically examined to exclude the presence of caries or periapical pathology. A standardized operative procedure is followed in both experimental groups. Thermal testing (K€altespray; M&W Dental GmbH, B€udingen, Germany) will perform to assess pulp vitality. Before cavity preparation, teeth will mechanically be cleaned and disinfected with 0.2% chlorhexidine solution. After local anesthesia (Iran-Darou pakhsh) and rubber dam application, occlusal Class I cavities will prepare by using round sterile diamond burs at high speed under air-distillated water spray coolant. An exposure of approximately 1.2 mm in diameter will be made with round carbide burs (4 1.2 mm) under sterile saline cooling. New burs will be used during each operation. Bleeding will be controlled with saline irrigation, and a sterile cotton pellet is placed onto the pulp exposure sites. In group 1 the pulps and the surrounding dentins will be capped with Retro-MTA as an interventive group.Reto-MTA is a hydraulic bioceramic material for repair and vital pulp therapy. Retro-MTA is powder consisting of fine,hydrophilic particles that set in the presence of water and form a strong impermeable barrier.it contains hydraulic calcium zirconia complex as a contrast media.setting time is 150 seconds.it has no discoloration even in the blood contamination.it has no toxicity to cells in 48 hours.this means it is a ideal substance for vital pulp therapy.fast setting,no discoloration,no heavy metal,no cell toxicity,good handeling properties and economic price are some of sultaible properties of Retro-MTA.in vivo condition Ph is up to 12/5and down to 7.8-8 in 4 weeks.Ex vivo study shows it has the high potential for biomineralization. هی 0/3 gram Retro root-MTA powder with 3 drops of water will be mixed by a plastic spatula for 20 seconds until the shiny surface disappears. The teeth will be provisionally restored with glass ionomer cement (Ketac Molar; 3M ESPE, Seefeld, Germany). 2 months later, patients will return back and after clinical and radiographical examinations, the teeth will be extracted and sent to a talented pathologist for histological examinations.All the clinical procedures will be performed by one experienced operator (A.N.) in the Endodontic Department of Islamic Azad Dental university of Tehran. Intervention 2: Before the operative protocol, each tooth will be radiologically examined to exclude the presence of caries or periapical pathology. A standardized operative procedure is followed in both experimental groups. Thermal testing (K€altespray; M&W Dental GmbH, B€udingen, Germany) will perform to assess pulp vitality. Before cavity preparation, teeth will mechanically be cleaned and disinfected with 0.2% chlorhexidine solution. After local anesthesia (Iran-Darou pakhsh) and rubber dam application, occlusal Class I cavities will prepare by using round sterile diamond burs at high speed under air-distillated water spray coolant. An exposure of approximately 1.2 mm in diameter will be made with round carbide burs (4 1.2 mm) under sterile saline cooling. New burs will be used during each operation. Bleeding will be controlled with saline irrigation, and a sterile cotton pellet is placed onto the pulp exposure sitesProRoot MTA(Dentsply-USA) is a water-based material which uses for apexification, repairing root perforations and As a pulp capping material.It sets in the presence of moisture. The main constituent phases are tricalcium and dicalcium silicate and tricalcium aluminate.In group II exposed pulps and the surrounding dentins will be capped with Retro-MTA.0/3 gram Retro root-MTA powder with 3 drops of water will be mixed by a plastic spatula for 20 seconds until the shiny surface disappears. 2 months later, patients will return back and after clinical and radiographical examinations, the teeth will be extracted and sent to a talented pathologist for histological examinations.All procedures will be performed by one experienced operator (A.N.) in the Endodontic Department of Dental School.
public Hengameh Bakhtiar
Unit2, No10, Gandi st, Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 8820 2705 H_Bakhtiar@dentaliau.ac.ir Islamic Azad Dental university scientific Hengameh Bakhtiar
Unit2, No10, Gandi st, Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 8820 2705 h_Bakhtiar@dentaliau.ac.ir Islamic Azad Dental university Iran (Islamic Republic of) Inclusion criteria: age between18-32 years old; erupted third molar; closed apex; caries free; normal sign to vitality tests. Exclusion criteria: external or internal resorptin; peri apical lesion. 18 years 32 years Both IA49.1 Infection disease Treatment - Other Treatment - Other Before the operative protocol, each tooth will be radiologically examined to exclude the presence of caries or periapical pathology. A standardized operative procedure is followed in both experimental groups. Thermal testing (K€altespray; M&W Dental GmbH, B€udingen, Germany) will perform to assess pulp vitality. Before cavity preparation, teeth will mechanically be cleaned and disinfected with 0.2% chlorhexidine solution. After local anesthesia (Iran-Darou pakhsh) and rubber dam application, occlusal Class I cavities will prepare by using round sterile diamond burs at high speed under air-distillated water spray coolant. An exposure of approximately 1.2 mm in diameter will be made with round carbide burs (4 1.2 mm) under sterile saline cooling. New burs will be used during each operation. Bleeding will be controlled with saline irrigation, and a sterile cotton pellet is placed onto the pulp exposure sites. In group 1 the pulps and the surrounding dentins will be capped with Retro-MTA as an interventive group.Reto-MTA is a hydraulic bioceramic material for repair and vital pulp therapy. Retro-MTA is powder consisting of fine,hydrophilic particles that set in the presence of water and form a strong impermeable barrier.it contains hydraulic calcium zirconia complex as a contrast media.setting time is 150 seconds.it has no discoloration even in the blood contamination.it has no toxicity to cells in 48 hours.this means it is a ideal substance for vital pulp therapy.fast setting,no discoloration,no heavy metal,no cell toxicity,good handeling properties and economic price are some of sultaible properties of Retro-MTA.in vivo condition Ph is up to 12/5and down to 7.8-8 in 4 weeks.Ex vivo study shows it has the high potential for biomineralization. هی 0/3 gram Retro root-MTA powder with 3 drops of water will be mixed by a plastic spatula for 20 seconds until the shiny surface disappears. The teeth will be provisionally restored with glass ionomer cement (Ketac Molar; 3M ESPE, Seefeld, Germany). 2 months later, patients will return back and after clinical and radiographical examinations, the teeth will be extracted and sent to a talented pathologist for histological examinations.All the clinical procedures will be performed by one experienced operator (A.N.) in the Endodontic Department of Islamic Azad Dental university of Tehran. Before the operative protocol, each tooth will be radiologically examined to exclude the presence of caries or periapical pathology. A standardized operative procedure is followed in both experimental groups. Thermal testing (K€altespray; M&W Dental GmbH, B€udingen, Germany) will perform to assess pulp vitality. Before cavity preparation, teeth will mechanically be cleaned and disinfected with 0.2% chlorhexidine solution. After local anesthesia (Iran-Darou pakhsh) and rubber dam application, occlusal Class I cavities will prepare by using round sterile diamond burs at high speed under air-distillated water spray coolant. An exposure of approximately 1.2 mm in diameter will be made with round carbide burs (4 1.2 mm) under sterile saline cooling. New burs will be used during each operation. Bleeding will be controlled with saline irrigation, and a sterile cotton pellet is placed onto the pulp exposure sitesProRoot MTA(Dentsply-USA) is a water-based material which uses for apexification, repairing root perforations and As a pulp capping material.It sets in the presence of moisture. The main constituent phases are tricalcium and dicalcium silicate and tricalcium aluminate.In group II exposed pulps and the surrounding dentins will be capped with Retro-MTA.0/3 gram Retro root-MTA powder with 3 drops of water will be mixed by a plastic spatula for 20 seconds until the shiny surface disappears. 2 months later, patients will return back and after clinical and radiographical examinations, the teeth will be extracted and sent to a talented pathologist for histological examinations.All procedures will be performed by one experienced operator (A.N.) in the Endodontic Department of Dental School. Pulp health(Post Operative sensitivity and pain ). Timepoint: After treatment,1 week later and before extraction. Method of measurement: Vitality test,Cold test and EPT. Signs of periapical pathology. Timepoint: Radiographs are taken before intervention and extraction. Method of measurement: PA Radiography. Dentin barrier formation. Timepoint: Eight weeks after beginning treatment. Method of measurement: Histological examination after extraction. Vice challenger of research,Islamic Azad Dental University of Tehran Approved 2015-06-14 Moral Committee of Islamic Azad Dental university of Tehran Azad Dental School, #10 Neyestan , Pasdaran Ave,Tehran,Iran Tehran Iran (Islamic Republic of)