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IRCT2014101919584N1 IRCT 2014-12-30 Vice chancellor for research, Isfahan university of medical sciences Using different modes of ventilation after coronary artery bypass graft surgery Determining and comparing the effect of Adaptive Support Ventilation and Synchronized Intermittent Mandatory Ventilation on respiratory support outcomes after Coronary Artery Bypass Graft surgery, Isfahan University of Medical sciences, Chamran hospital, 2014 2014-04-21 anticipated 64 Complete https://irct.ir/trial/17500 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. 2-3 Atherosclerotic heart disease. Intervention 1: Description: In this study, patients after undergoing Coronary Artery Bypass Graft surgery (CABG) and transferring to the intensive care unit (ICU) while intubated, with approval of an anesthesiologist for posibility of using one of the Adaptive Support Ventilation (ASV) or Synchronized Intermittent Mandatory Ventilation (SIMV) modes, were randomized to the intervention or control group. Intervention group: using Adaptive Support Ventilation mode for respiratory ventilation after coronary artery bypass graft surgery in intensive care unit. Intervention 2: Control group: Using Synchronized Intermittent Mandatory Ventilation mode for respiratory ventilation after coronary artery bypass graft surgery in intensive care unit.
public Hadi Zarei
Isfahan university of medical sciences, faculty of nursing and midwifery, Hezar Jarib street, Azadi square, Isfahan
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3792 2901 hadi.zarei767@gmail.com Isfahan university of medical sciences, faculty of nursing and midwifery scientific Hadi Zarei
Faculty of nursing and midwifery, Isfahan university of medical sciences, Hezar Jarib street, Isfahan
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3791 2901 hadi.zarei767@gmail.com Isfahan university of medical sciences, faculty of nursing and midwifery Iran (Islamic Republic of) Main inclusion criteria: Using one of the ventilation modes (Adaptive support ventilation (ASV) or synchronized intermittent mandatory ventilation (SIMV)) on Raphael ventilator was allowed by anesthesiologist; The range of age was between 25 and 65 years; Patients did not have a history of lung diseases (Asthma, ...) or lung and heart surgeries; Patients did not have renal failure (serum creatinine more than 2), liver disease, and history of seizure and CVA; left ventricular ejection fraction was more than 30 percent; In the time of ICU entrance patients were haemodynamically stable ( respiratory rate less than 35 per minute, heart rate less than 150 per minute, mean atrial pressure less than 70 mmHg) and intra aortic balloon pump was not used. Main exclusion criteria: occurring unstable haemodynamic status during research (respiratory rate more than 35 per minute, heart rate more than 150 per minute, mean atrial pressure more than 70 mmHg); life threatening arrhythmia durin research like ventricular tachycardia; need to excess dosages of inotropes and vasoconstrictors during research (Dopamin more than 20 milligram per hour, norepinephrin more than 0.5 milligram per hour, dobotamin more than 25 milligram per hour, and epinephrin with any doses); Unusual bleeding after operation (chest tube drainage more than 500 ml per hour, more than 350 ml per hour for 2 hours, or more than 1000 ml at all) ; Need to anesthesia and operation again. 25 years 65 years Both IX125.1 Atherosclerotic heart disease Treatment - Other Treatment - Drugs Description: In this study, patients after undergoing Coronary Artery Bypass Graft surgery (CABG) and transferring to the intensive care unit (ICU) while intubated, with approval of an anesthesiologist for posibility of using one of the Adaptive Support Ventilation (ASV) or Synchronized Intermittent Mandatory Ventilation (SIMV) modes, were randomized to the intervention or control group. Intervention group: using Adaptive Support Ventilation mode for respiratory ventilation after coronary artery bypass graft surgery in intensive care unit Control group: Using Synchronized Intermittent Mandatory Ventilation mode for respiratory ventilation after coronary artery bypass graft surgery in intensive care unit Intubation duration. Timepoint: When the intervention starts. Method of measurement: Hour and minutes. Length of hospital stay. Timepoint: When the patient is being discharged. Method of measurement: Hour and minutes. Nothing. Timepoint: nothing. Method of measurement: nothing. Vice chancellor for research, Isfahan university of medical sciences Approved 2014-05-08 Moral committee of Isfahan university of medical sciences Isfahan university of medical sciences, Azadi squre, Hezar Jarib street, Isfahan Isfahan Iran (Islamic Republic of)