IRCT2017042919554N12 IRCT 2017-10-27 Vice chancellor for research, Zanjan University of Medical Sciences. The effect of vitamin D deficiency treatment on dyspnea severity in patients with COPD Comparison of the effect of vitamin D and placebo on clinical and spirometric indices in patients with chronic obstructive pulmonary disease (COPD). 2016-07-20 anticipated 60 Complete https://irct.ir/trial/17481 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: the patients categorized non-randomly into groups treated with vitamin D (with the assignment of zero and even numbers) and placebo (by assigning individual numbers). 2 Chronic Obstructive Pulmonary Disease. Intervention 1: Intervention group: 50000 IU Pearl vitamin D every week and 500mg calcium-D tablet daily (for three month). Intervention 2: Control group: Perl placebo every week and calcium-D 500 mg tablets daily (for three months).

public Maryam Jameshorani

Valiasr hospital, Valiasr Sq., Zanjan

Zanjan Iran (Islamic Republic of) 4515777978 +98 24 3377 0723 ZMDRC@zums.ac.ir Zanjan University of Medical Sciences scientific Maryam Jameshorani

Valiasr hospital, Valiasr Sq.,Zanjan

Zanjan Iran (Islamic Republic of) 4515777978 +98 24 3377 0723 ZMDRC@zums.ac.ir Zanjan University of Medical Sciences Iran (Islamic Republic of) Inclusion Criteria: Outpatients suffering from COPD who haven’t had COPD exacerbation in last 2 weeks; serum vitamin D level less than 30 ng / dl; written consent for participating in the study. Exclusion Criteria: liver problems (LFT equal to or more than 2 times more than normal); renal failure (GFR<60); Granulomatous diseases (including tuberculosis, sarcoidosis); malnutrition; malabsorption (including IBD and Celiac); any types of cancer; parathyroid disease. 30 years 80 years Both J43, J44.8 Emphysema -Other specified chronic obstructive pulmonary disease-Chronic obstructive pulmonary disease, unspecified- - Treatment - Drugs Placebo Intervention group: 50000 IU Pearl vitamin D every week and 500mg calcium-D tablet daily (for three month) Control group: Perl placebo every week and calcium-D 500 mg tablets daily (for three months) Forced expiratory volume (FEV1). Timepoint: Before the intervention and three months after the end of intervention. Method of measurement: spirometery. Forced expiratory volume 1/ Forced vital capacity(FEV1/FVC). Timepoint: Before the intervention and three months after the end of intervention. Method of measurement: Spirometry. Severity of Dyspnea. Timepoint: Before the intervention and three months after the end of intervention. Method of measurement: MRC Dyspnoea Scale. Weight. Timepoint: Before the intervention and three months after the end of intervention. Method of measurement: Scale. Vice chancellor for research, Zanjan University of Medical Sciences. Approved 2016-11-23 Ethics committee of Zanjan University of Medical Sciences Zanjan University of Medical Sciences, Karmandan street, Zanjan Zanjan Iran (Islamic Republic of)