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IRCT2016082719470N42 IRCT 2017-10-01 Vice Chancellor for Research, Shiraz University of Medical Sciences To investigate the post – operative analgesic effect of intra – articular magnesium sulfate / Bupivacaine compared with Tramadol / Bupivacaine after knee arthroscopic surgeries. To investigate the post – operative analgesic effect of intra – articular magnesium sulfate and Bupivacaine compared with Tramadol and Bupivacaine after knee arthroscopic surgeries. 2017-06-22 anticipated 43 Complete https://irct.ir/trial/17415 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: Random Number Table is method for randomization. 2-3 arthrosis of knee. Intervention 1: The first intervention group (T): patients received 100 mg tramadol (50 mg / ml ampoule, Tehran Chemie Pharmaceutical, Tehran, Iran) with 50 mg bupivacaine 0.25% (Bupivacaine-Milan 0.5%, Willy 20 Ml, Mylan, France) so that the final volume of solution is adjusted to 20 ml with normal saline and injected into the joint at the end of the surgery. Intervention 2: The second intervention group (M): patients received 2 g magnesium sulfate (magnesium sulfate 50%, 50 ml vial., Pasteur Institute of Iran, Tehran, Iran) with 0.5 mg bupivacaine (0.25%) as the final volume with saline solution will be 20 ml and injected at the end of the joint operation.
public Afshin Zarei
Anesthesiology Department- Faghihi Hospital- Zand Street
Shiraz Iran (Islamic Republic of) +98 71 3647 4270 masihifarzaneh@yahoo.com Shiraz University of Medical Sciences scientific Dr Sina Gafari
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) +98 71 3647 4270 sighafari@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Aged over 19 and under 65 years old; (ASA I-II). Exclusion criteria: Biopsy or simple knee washing; chronic use of opium or tramadol. 19 years 65 years Both M17 Gonarthrosis [arthrosis of knee] Treatment - Drugs Treatment - Drugs The first intervention group (T): patients received 100 mg tramadol (50 mg / ml ampoule, Tehran Chemie Pharmaceutical, Tehran, Iran) with 50 mg bupivacaine 0.25% (Bupivacaine-Milan 0.5%, Willy 20 Ml, Mylan, France) so that the final volume of solution is adjusted to 20 ml with normal saline and injected into the joint at the end of the surgery. The second intervention group (M): patients received 2 g magnesium sulfate (magnesium sulfate 50%, 50 ml vial., Pasteur Institute of Iran, Tehran, Iran) with 0.5 mg bupivacaine (0.25%) as the final volume with saline solution will be 20 ml and injected at the end of the joint operation. Pain score. Timepoint: before surgical procedure, in the recovery and 24 hours after surgery. Method of measurement: VAS(visual analog scale). The morphine IV, PCA pumps and total morphine consumption. Timepoint: 24 hours after surgery at 2, 4, 6, 8, 12, 16, 20, and 24. Method of measurement: Observasion. Any side effects of analgesics. Timepoint: 24 hours after surgery at 2, 4, 6, 8, 12, 16, 20, and 24. Method of measurement: Observasion. Patients stisfaction. Timepoint: After surgery in the ward. Method of measurement: Questionnaire. Vice Chancellor for Research, Shiraz University of Medical Sciences Approved 2017-04-21 Ethics committee of Shiraz University of Medical Sciences Vice Chancellor of research, Shiraz University of Medical Sciences, 7th floor, central building of Shiraz University of Medical Sciences, Zand street Shiraz Iran (Islamic Republic of)