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IRCT2014100719431N1 IRCT 2015-01-12 Iran University of Medical Science Effect of Hyoscine and Atropine on blood pressure ,heart rate in patient who treated by ECT Comparisson of the effect of pretreatment with Hyoscine,Atropine and placebo on hemodynamic stability,recovery time,and ECT side effect 2014-03-20 anticipated 60 Complete https://irct.ir/trial/17365 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Condition 1: Schizophrenia. Condition 2: Persistant delusional disorders. Condition 3: Acute and transient psychotic disorder. Condition 4: Manic disorder. Condition 5: Bipolar mood diorder. Condition 6: Depressive episode. Condition 7: Paranoid personality disorder. Intervention 1: 20 patients accidentally are belong to first group.after initial monitoring and record of information,vital signs include systolic and diastolic blood pressure,pulse rate are recorded in data sheath.in this group all patient recive intravenous atropine 0.5mg (0.01 mg/kg) as pretreatment.induction of anesthesia is done with nesdonal 2mg/kg and succynil choline 0.5 mg/kg. in all patients,blood pressure and pulse rate,time of consciousness ,recovery time, volume of respiratory secretions ,duration of convulsion will be record. Intervention 2: 20 patients accidentally are belong to second group.after initial monitoring and record of information,vital signs include systolic and diastolic blood pressure,pulse rate are recorded in data sheath.in this group all patient recive intravenous hyoscine 5-7mg (0.1 mg/kg) as pretreatment.induction of anesthesia is done with nesdonal 2mg/kg and succynil choline 0.5 mg/kg. in all patients,blood pressure and pulse rate ,time of consciousness ,recovery time, volume of respiratory secretions ,duration of convulsion will be record. Intervention 3: 20 patients accidentally are belong to third group.after initial monitoring and record of information,vital signs include systolic and diastolic blood pressure,pulse rate are recorded in data sheath.in this group all patient recive intravenous sterile water 1 ml (0.01 ml/kg) as pretreatment.induction of anesthesia is done with nesdonal 2mg/kg and succynil choline 0.5 mg/kg. in all patients,blood pressure and pulse rate ,time of consciousness ,recovery time, volume of respiratory secretions ,duration of convulsion will be record.
public Behnaz Karimi
Anesthesiology Department of Hazrat Rasool Akram Hospital, Niayesh street, Sattarkhan, Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 4476 3217 karimi.behnaz@gmail.com Iran University of Medical Science scientific Dr Ali Khatibi
Anesthesiology Department of Firoozgar Hospital, Vali asr street, Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 6650 9059 alikhatibi2002@yahoo.com khatibi Iran University of Medical Science Iran (Islamic Republic of) patients according to psychological indication and psychologist confirmation are entered to study patients excep who are older than 70 and those have medical contraindication for atropine and hyoscine. patients have tachy cardia,bradycardia,arrythmia,hypotension and hypertension are excluded. no limit 70 years Both F20 F22 F23 F30 F31 F32 F60.0 Schizophrenia Persistant delusional disorder Acute and transient psychotic disorder Manic episode Bipolar affective disorder Depressive episode Paranoid personality disorder Treatment - Drugs Treatment - Drugs Treatment - Drugs 20 patients accidentally are belong to first group.after initial monitoring and record of information,vital signs include systolic and diastolic blood pressure,pulse rate are recorded in data sheath.in this group all patient recive intravenous atropine 0.5mg (0.01 mg/kg) as pretreatment.induction of anesthesia is done with nesdonal 2mg/kg and succynil choline 0.5 mg/kg. in all patients,blood pressure and pulse rate,time of consciousness ,recovery time, volume of respiratory secretions ,duration of convulsion will be record. 20 patients accidentally are belong to second group.after initial monitoring and record of information,vital signs include systolic and diastolic blood pressure,pulse rate are recorded in data sheath.in this group all patient recive intravenous hyoscine 5-7mg (0.1 mg/kg) as pretreatment.induction of anesthesia is done with nesdonal 2mg/kg and succynil choline 0.5 mg/kg. in all patients,blood pressure and pulse rate ,time of consciousness ,recovery time, volume of respiratory secretions ,duration of convulsion will be record. 20 patients accidentally are belong to third group.after initial monitoring and record of information,vital signs include systolic and diastolic blood pressure,pulse rate are recorded in data sheath.in this group all patient recive intravenous sterile water 1 ml (0.01 ml/kg) as pretreatment.induction of anesthesia is done with nesdonal 2mg/kg and succynil choline 0.5 mg/kg. in all patients,blood pressure and pulse rate ,time of consciousness ,recovery time, volume of respiratory secretions ,duration of convulsion will be record. Heart rate. Timepoint: after and before pretreatment and after induction and immediately ,after 1,3 and 5 minutes from shock ,heart rate is measured in all patients. Method of measurement: heart rate is measuring by ECG monitoring. Duration of convulsion. Timepoint: after shock,from the firs movements of patientsto end of convulsion,time is recorded. Method of measurement: duration of convulsion is measured according to seconds. Time of recovery. Timepoint: from termination of convulsion to allertness of patient is called as recovery time.alertness means the ability of patients to obey orders. Method of measurement: time of recovery,allertness and obey is measuring according minutes. Volume of respiratory secretions. Timepoint: by convulsion termination ,respiratory secretions may ecceed normal amounts ,so we should suction them. Method of measurement: volume of secretions is measured according to how many times to sucction(1-3 times )1:dry 2:sialorrhea 3:huge amounts of secretions. Blood pressure. Timepoint: after and before pretreatment and after induction and immediately ,after 1,3 and 5 minutes from shock ,blood pressure is measured in all patients. Method of measurement: blood pressure is measured by cuff around patients arm. Cognition disorders. Timepoint: cognition disorders are recorded during recovery time. Method of measurement: cognition disorders according to diagnosis confirmation by psychologist. Other complications. Timepoint: from the patients entrance to end of recovery. Method of measurement: every other complication occurs is recorded by inspection and visualization. Primary diagnosis. Timepoint: at first after patients entrance, primary diagnosis is recorded in data sheet. Method of measurement: at first primary diagnosis is recorded from medical records. Age. Timepoint: at first after patients entrance, age is recorded. Method of measurement: age is recorded according to medical records. Sex. Timepoint: at first,after patients entrance, sex is recorded. Method of measurement: at first sex is recorded from medical records. Iran University of Medical Science Approved 2014-03-05 Iran University of Medical Science Hemmat High way Tehran Iran (Islamic Republic of)