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IRCT2014092819320N1 IRCT 2014-11-01 Vice chancellor for research of Isfahan Univercity of Medical science Effect of memantin in treatment of patients with schizophrenia The comparison effect of memantin in improvement of quality of life and global function in patients with schizophrenia 2013-07-06 anticipated 64 Complete https://irct.ir/trial/17303 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A schizophrenia. Intervention 1: control group:placebo tablet that is similar to memantin in shape,size and color. starting with single dose 5mg per day then increase 5mg each week ,up to 10 mg at morning and 10 mg at night after 4 weeks and continuation (10 mg BD)to12 weeks. Intervention 2: study group : memantine tab,starting with single dose 5mg per day then increase 5mg each week ,up to 10 mg at morning and 10 mg at night after 4 weeks and continue (10 mg BD)to12 weeks.
public Mohammadian Sichani Maryam
University of medical Sciences, avenue Hezar jeribe, Isfahan, Iran
Isfahan Iran (Islamic Republic of) +98 31 3222 2475 farshid5@sepahan.iut.ac.ir; Mohammadian99@yahoo.com Isfahan University of Medical Sciences scientific Mohammadian Sichani Maryam
Univercity of Medical Science, Avenue Hezar jerib, Isfahan, Iran
Isfahan Iran (Islamic Republic of) +98 31 3222 2475 farshid5@sepahan.iut.ac.ir ; Mohammadian99@Yahoo.com Isfahan Univercity of Medical Science Iran (Islamic Republic of) inclusion criteria:age group 18-65 ; no mental retardation ;no pregnancy or milking ;diagnosis of schizophrenia for at least 2 years;treatment with atypical anti psychotic from 3 month ago;do not have ECT during 2 week ago Exclusion criteria:allergic to memantin;addiction or dependency to substance or drugs ;other psychiatric disorder or serious neurological deficit. 18 years 65 years Both F20,F21,F2 Schizophrenia, schizotypal and delusional disorder Placebo Treatment - Drugs control group:placebo tablet that is similar to memantin in shape,size and color. starting with single dose 5mg per day then increase 5mg each week ,up to 10 mg at morning and 10 mg at night after 4 weeks and continuation (10 mg BD)to12 weeks. study group : memantine tab,starting with single dose 5mg per day then increase 5mg each week ,up to 10 mg at morning and 10 mg at night after 4 weeks and continue (10 mg BD)to12 weeks. Quality of life. Timepoint: at base line,each 4 weeks to 12weeks. Method of measurement: Quality Of Life scale of schizophrenia. Global Function. Timepoint: at baseline,each 4 weeks to 12weeks. Method of measurement: Global Assesment Of Functioning. Possitive and negative symptoms. Timepoint: at base line, each 4 weeks to12 weeks. Method of measurement: Possitive And Negative Symptom Scale. Depression. Timepoint: at base line,each 4 weeks to12 weeks. Method of measurement: Calgary Depressive Scale for Schizophrenia. Side effects. Timepoint: during 12 weeks of study. Method of measurement: history of patient and his/her companion and physical exam. Vice chancellor for research of Isfahan Univercity of Medical science Approved 2013-05-29 Ethics committee of Isfahan Univercity of Medical Sciences Isfahan Univercity of Medical Science,Aven Hezar Jerib ÙˆIsfahan,IRAN Isfahan Iran (Islamic Republic of)