IRCT2014090219021N1 IRCT 2014-09-13 Isfahan University of Medical Sciences Effect of Sodium Bicarbonate Buffered Lidocaine 2% in the treatment of teeth with acute pain Effect of Sodium Bicarbonate Buffered Lidocaine 2% on the Success of Inferior Alveolar Nerve Block for Teeth with Symptomatic Irreversible Pulpitis 2014-09-13 anticipated 80 Complete https://irct.ir/trial/17116 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Irreversible pulpitis. Intervention 1: patients will divided into two groups. 2 inferior alveolar nerve block with 2 similar cartridges will be injectet to each patient. . Endodontic access preparation will be begun 15 minutes after injection. Lip numbness is required for all patients.the patients in the control group will be received two cartridges of 1.5 mL of 2% lidocaine (Lignospan; Septodont, Saint Maur des Fosses, France) with 1:80,000 epinephrine with 0.3 mL sterile distilled water. Intervention 2: patients will divided into two groups. 2 inferior alveolar nerve block with 2 similar cartridges will be injectet to each patient. . Endodontic access preparation will be begun 15 minutes after injection. Lip numbness is required for all patients.the patients in the first experimental group will be received two cartridges of 1.5 mL of 2% lidocaine with 1:80,000 epinephrine(Lignospan; Septodont, Saint Maur des Fosses, France) buffered with 0.3 mL of 8.4% sodium bicarbonate (8.4% weight/volume, 50 mEq/50 mL, Samen Laboratories, Iran).