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IRCT138804062083N1 IRCT 2010-06-19 Research Department, Mashhad University of Medical Sciences A comparative study of therapeutic effects of garlic and penicillamine in patients with chronic occupational lead poisoning A comparative study of therapeutic effects of garlic and penicillamine in patients with chronic occupational lead poisoning 2010-06-21 anticipated 76 Complete https://irct.ir/trial/1692 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Lead poisoning. Intervention 1: Penicillamine Cap 250 mg 4 times daily for 4 weeks. Intervention 2: Garlic Tab 400 mg 4 times daily for 4 weeks (each tablet contains 1200 microgram allicin).
public Dr. Mahdi Balali Mood
Imam Reza Hospital - Medical Toxicology Center
Mashhad Iran (Islamic Republic of) +98 51 1859 8973 mbalalimood@hotmail.com ; balalimoodm@mums.ac.ir Medical Toxicology Center scientific Dr. Mahdi Balali Mood
Imam Reza Hospital - Medical Toxicology Center
Mashhad Iran (Islamic Republic of) +98 51 1859 8973 mbalalimood@hotmail.com ; balalimoodm@mums.ac.ir Medical Toxicology Center Iran (Islamic Republic of) Inclusion criteria: employees who has worked more than one year in a car battery industry, blood lead levels of 200-500 μg/L Exclusion criteria: family history of allergy to penicillin and drugs that have cross-sensitivity to penicillin, antimalarial drugs and gold salt, history of agranolocytosis or anemia in previous use of penicillamine, known heart, liver or renal failure, hypersensitivity to garlic, hemorrhagic diathesis, elective surgery during and 10 days after the consumption of garlic, using antibiotics or anticoagulant drugs no limit no limit Male T56.0 Toxic effects of lead and its compounds Treatment - Drugs Treatment - Drugs Penicillamine Cap 250 mg 4 times daily for 4 weeks Garlic Tab 400 mg 4 times daily for 4 weeks (each tablet contains 1200 microgram allicin) Blood lead levels. Timepoint: Baseline and 1 month after the intervention. Method of measurement: by atomic absorption device, model Perkin Elmer 3030, through the technique of Heated Graphite Atomization. Signs and symptoms. Timepoint: Baseline and 1 month after the intervention. Method of measurement: medical examination. Side effects. Timepoint: routine medical examination to find possible abnormal signs and symptoms - Complete blood count 15 days after the initiation of intervention. Method of measurement: Routine medical examination - Complete blood count 15 days after the initation of treatment. Blood sugar. Timepoint: Baseline and 1 month after the intervention. Method of measurement: laboratory testing. Liid profile invluding (cholestrol, triglyceride, HDL and LDL). Timepoint: Baseline and one month after the intervention. Method of measurement: laboratory testing. Research Department, Mashhad University of Medical Sciences Approved 2009-04-11 Research Department, Mashad University of Medical Sciences 2nd floor - (Central Department of Mashad University of Medical Sciences (Ghoreyshi building) - Daneshgah avenue Mashad Iran (Islamic Republic of)