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IRCT2014081018662N1 IRCT 2014-08-21 Avicenna Infertility Clinic Effect of vitamin E, vitamin D on treatment of infertility in PCOS patients Evaluation of the effect of supplementation with vitamin E and vitamin D on serum and follicular fluid oxidative and anti oxidative stress factors, oocyte quality and ICSI outcomes in PCOS infertile women candidate for ICSI who referred to Infertility Clinic of Avicenna Research Center during 2014-2015 2014-08-23 anticipated 100 Complete https://irct.ir/trial/16859 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Basic scienece. 2-3 Condition 1: Polycystic ovarian syndrome. Condition 2: Infertility. Intervention 1: placebo of vit E once daily for 2 months. Intervention 2: pearl vit D,Biweekly for 2 months. Intervention 3: placebo of vit D,biweekly for 2 months. Intervention 4: pearl vit E,400 IU,once daily for 2 months.
public Dr. Farnaz Fatemi
No. 97, Yakhchal st., Shariati avenu,Tehran, Iran
Tehran Iran (Islamic Republic of) 1941913114 +98 21 23519 f.fatemi@avicenna.ac.ir Avicenna Infertility Clinic scientific Dr. Farnaz Fatemi
No. 97, Yakhchal st., Shariati avenu,Tehran, Iran
Tehran Iran (Islamic Republic of) 1941913114 +98 21 23519 f.fatemi@avicenna.ac.ir Avicenna Infertility Clinic Iran (Islamic Republic of) Inclusion criteria: PCOS patients based on ROTERDOM criteria; age:18-38 years old; day3 FSH level less than 12; BMI:20-34. Exclusion criteria: patients with heart, liver or renal disease; patients with Endometriosis; use of anticoagulats: ASA, Heparin, Warfarin; use of antidepresants:Fluoxetin, Certeralin; use of Statins: Levastatin, Atorvastatin; patients with Eye disease: Retinitis pigmentosa; use of anti inflammatory drugs and corticosteroids:prednisolon; use of vitamins and anti oxidants in 3 months ago; vit K deficiency and bleeding disorders; history of chemotherapy or radiotherapy 18 years 38 years Female E28.2 Z31.2 Sclerocystic ovary syndromeStein-Leventhal syndrome In vitro fertilization Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs placebo of vit E once daily for 2 months pearl vit D,Biweekly for 2 months placebo of vit D,biweekly for 2 months pearl vit E,400 IU,once daily for 2 months Serum malondealdehyde. Timepoint: before intervention and after intervention on the oocyte collection day. Method of measurement: American key man kit. Serum total antioxidant capaity(TAC). Timepoint: before intervention and after intervention on the oocyte collection day. Method of measurement: American key man kit. Serum super oxid dismuthase. Timepoint: before intervention and after intervention on the oocyte collection day. Method of measurement: American key man kit. Follicular fluid malondealdehyde. Timepoint: on the oocyte collection day. Method of measurement: American key man kit. Follicular fluid total anti oxidant capacity. Timepoint: on the oocyte collection day. Method of measurement: American key man kit. Follicular fluid super oxid dismuthase. Timepoint: on the oocyte collection day. Method of measurement: American key man kit. Oocyte quality. Timepoint: on the day of oocyte collection. Method of measurement: morphologic assesment with microscope. ICSI outcome. Timepoint: 2 weeks after embryo transfer. Method of measurement: serum BHCG. Avicenna Infertility Clinic Approved 2014-06-24 Avicenna Research Institute Ethics Committee Avicenna Research Institute, Shahid Beheshti University, Velenjak Avenue, Chamran highway Tehran Iran (Islamic Republic of)