IRCT2016033118389N4 IRCT 2016-04-25 Qom University of Medical Sciences and Health Services Vice chancellor Effect of Nicorandil on contrast media-induced acute kidney injury A clinical trial of the comparison of the effect of oral Nicorandil plus hydration with hydration alone on serum creatinine in high-risk patients after receiving contrast 2016-04-20 anticipated 128 Complete https://irct.ir/trial/16696 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: Block Randomization: Block randomization is commonly used in two treatment situations where sample sizes for two treatments are to be equal or approximately equal. The process involves recruiting participants in short blocks and ensuring that half of the participants within each block are allocated to treatment “B” and the other half to “C”. Conceptually there are an infinite number of possible block sizes. Suppose we consider blocks of size four. There are six different ways that four patients can be split evenly between two treatments: 1. AABB, 2. ABAB 3. ABBA, 4. BAAB, 5. BABA, 6. BBAA The next step is to select randomly among these six different blocks for each group of four participants that are recruited. 3 Acute renal failure. Intervention 1: Control group: All patients will be received intravenous hydration (2 liters normal saline From 2 h before to 6 h after contrast intake). Intervention 2: Intervention group: All patients will be received Nicorandil 20 mg ٰtablet (two hours before contrast intake) plus intravenous hydration (2 liter Normal saline from 2 h before to 6 h after injection of contrast). Nicorandil, a nicotinamide derivative with the molecular formula C8H9N3O4 ; Causes sustained dilation of both the arterial resistance and conductive vessels. This drug is an anti-angina medication that has the dual properties of nitrate and K+ATP channel agonist.