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IRCT2014071418373N1 IRCT 2014-08-04 Umbilical Cord Stem Cell Research Center of Tabriz University of Medical Sciences Comparison Study of efficacy of skin pigment cell graft and topical calcipotriol cream with skin pigment cell graft in Treatment of Vitiligo Comparison Study of efficacy of basal cell layer suspension and topical calcipotriol with basal layer suspension in Treatment of Stable Vitiligo 2014-07-23 anticipated 20 Complete https://irct.ir/trial/16683 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Vitiligo. Intervention 1: In the first group : Epidermal basal cell suspension will inject in the dermabrassioned affected areas of Vitiligo, then grafted area will dress up by a tour of silicon covered with a layer of woven gauze moistened with saline compressed and covered with semi-permeable Tegaderm film. The dressing is removed after 8 days. After 6 months, the amount and quality of depigmentation of grafted area will be studied and compared with second group. To determine the recovery rate serial images will produce monthly and repigmentation will express as percentage. Intervention 2: In the second group :1 to 3 weeks after basal cell suspensions transplantation when wound healing is comlete, Calcipotriol will be applied topically once a day for 6 months and then the quality of repigmentation will be discussed. To determine the recovery rate serial images will produce monthly and repigmentation will express as percentage.
public Behzad Anosh
Dermatology ward, Sina Hospital, Azadi Ave
Tabriz Iran (Islamic Republic of) 00 behzadanosh@yahoo.com Tabriz University of Medical Sciences scientific Mohamad Reza Ranjkesh
Dermatology ward, Sina Hospital, Azadi Ave.
Tabriz Iran (Islamic Republic of) +98 41154121013 ranjkeshm@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients with 13 to 60 years old ; The number and size of lesions in at least two areas ; Leukoderma type ; stable vitiligo ; Lack of response to common treatment ; Consent to participate in the study. Exclusion criteria: The patients who have responded well to the treatment ; Patients with cardiovascular disorders ; People aged over 60 years ; Pregnant and lactating women ; Patients under 13 years old ; Patient with history of Koebner phenomenon ; Patient with history of hypertrophic scar tissue and colloid ; The patients with unstable vitiligo. 13 years 60 years Both L80 Vitiligo Treatment - Other Treatment - Other In the first group : Epidermal basal cell suspension will inject in the dermabrassioned affected areas of Vitiligo, then grafted area will dress up by a tour of silicon covered with a layer of woven gauze moistened with saline compressed and covered with semi-permeable Tegaderm film. The dressing is removed after 8 days. After 6 months, the amount and quality of depigmentation of grafted area will be studied and compared with second group. To determine the recovery rate serial images will produce monthly and repigmentation will express as percentage. In the second group :1 to 3 weeks after basal cell suspensions transplantation when wound healing is comlete, Calcipotriol will be applied topically once a day for 6 months and then the quality of repigmentation will be discussed. To determine the recovery rate serial images will produce monthly and repigmentation will express as percentage Pigmentation of skin with epidermal basal cell suspension grafting in the treatment of stable vitiligo. Timepoint: Baseline, after recovering of injection site and then monthly for 6 months. Method of measurement: Clinical observation. Pigmentation of skin with epidermal basal cell suspension grafting and Calcipotriol in the treatment of stable vitiligo. Timepoint: Baseline, after recovering of injection site and then monthly for 6 months. Method of measurement: Clinical observation. Umbilical Cord Stem Cell Research Center of Tabriz University of Medical Sciences Approved 2014-03-08 Ethics Committee of Tabriz University of Medical Sciences Tabriz University of Medical Sciences, Daneshgah Sq. Tabriz Iran (Islamic Republic of)