IRCT20090609002017N24 IRCT 2017-12-21 Nutritional Research Center Saffron effect on pancreatic beta cell pyroptosis in patients with type 2 diabetes Association between saffron supplementation and metabolic factors, serum oxidative stress indices and gene expression rate of pyroptosis related inflammatory factors in patients with type 2 diabetes 2017-12-22 anticipated 60 Complete https://irct.ir/trial/1643 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization will be used for each person by random numbers. due to proper allocation concealment, trial investigators and participants will be unaware of upcoming allocations, Blinding description: This is a double-blind study and both of the patients and researcher will be blind to group allocation. N/A Type 2 diabetes. Intervention 1: Saffron powder, 50 mg capsule, 2 per day, for 2 months. Intervention 2: Starch and dextrose powder, 50 mg capsule, 2 per day, for 2 months. No - There is not a plan to make this available Justification or reason for not sharing IPD is All data are resulting from dissertation and will be used just for manuscript printing in academic journals.