IRCT2014052817888N1 IRCT 2015-02-23 Mashhad University Of Medical Sciences ,Faculty Of Medicin To investigate anti-inflammatory and anti oxidative stress effects of Curcumin on sulfur mustard-induced lung complications in Iranian veterans To investigate anti-inflammatory and anti oxidative stress effects of Curcumin on sulfur mustard-induced lung complications in Iranian veterans 2012-08-22 anticipated 80 Complete https://irct.ir/trial/16355 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 1-2 Lung complications of Sulfur Mustard. Intervention 1: Patients: Curcumin will be administrated for the patients(N=20) in the form of C3 Complex capsules (500mg) twice a day, 1 capsule each 12 hours. Intervention 2: Controls:Placebo capsules will be used for the control group (N=20) containes piperine5 mg (500mg) , twice a day, 1 capsule each 12 hours. Placebo capsules are mached in shape and size with curcumin capsules.

public Zahra Khabjavid

N.679, Cheshmeh Alley, Nastaran St., Hasan Abad, Karaj, Alborz, Iran

Karaj Iran (Islamic Republic of) +98 912 867 5267 khabjavid@yahoo.com Mashhad University Of Medical Sciences ,Faculty Of Medicin, Department Of Biochemistry scientific Dr.Seyed Issac Hashemy

Mashhad University Of Medical Sciences, Faculty Of Medicin, Department Of Biochemistry, Azadi Square, Mashhad, KhorasaneRazavi, Iran

Mashhad Iran (Islamic Republic of) +98 51 3882 8573 hashemyi@mums.ac.ir Mashhad University Of Medical Sciences ,Faculty Of Medicin, Department Of Biochemistry Iran (Islamic Republic of) Inclusion criteria: Chemical injuries resulting from mustard gas with pulmonary complications, according to medical records at three levels of severity (mild, moderate, severe) according to PFTs results Exclusion criteria: History of allergy to herbal medicine; The need for hospitalization due to the severity of the disease; Taking any antioxidant supplements (vitamin C, E or selenium) at least two weeks before participating in the project ; Contact with a chemical gas in a business environment; smoking . 25 years 60 years Male T97 عوارض واثرات سمی ترکیبات با منابع غیر دارویی Treatment - Drugs Treatment - Drugs Patients: Curcumin will be administrated for the patients(N=20) in the form of C3 Complex capsules (500mg) twice a day, 1 capsule each 12 hours. Controls:Placebo capsules will be used for the control group (N=20) containes piperine5 mg (500mg) , twice a day, 1 capsule each 12 hours. Placebo capsules are mached in shape and size with curcumin capsules. FEV1. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: spirometery test. FVC. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: spirometery test. FEV1/FVC. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: spirometery test. IL-4. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. IL-8. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. IL-13. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. TNF-α. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. MCP-1. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. LDL. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. HDL. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. Total Cholestrol. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. TG. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. Lp[a]. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. SOD. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. MDA. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. CAT. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. IgE. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. IgG. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. H-Cys. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Serum analysis. Weight. Timepoint: Pre- trial -Pre- trial – 2 month later. Method of measurement: Kg. Chemical Injuries Research Center of Baqiyatallah University of Medical Sciences Mashhad University Of Medical Sciences ,Faculty Of Medicin Chemical Injuries Research Center of Baqiyatallah University of Medical Sciences Approved 2011-12-01 Baghiatallah University of Medical Sciences Molla Sadra Str - Tehran Tehran Iran (Islamic Republic of)