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IRCT2015102817867N3 IRCT 2017-06-10 Tehran University of Medical Sciences - Double stimulation versus single stimulation in rehabilitation of stroke patients using transcranial direct current stimulation Double point versus single point stimulation in motor rehabilitation of paretic arms among stroke patients using transcranial direct current stimulation 2017-06-22 anticipated 60 Complete https://irct.ir/trial/16338 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Ischemic Stroke. Intervention 1: Intervention group: Brain stimulation will be done through a battery-driven constant current stimulator. Each patient's brain will be stimulated in five sessions in five consecutive days for about an hour per session. In the first 30 minutes, primary motor cortex will receive real stimulation. Anode electrode will be placed over the injured hemisphere and cathode electrode will be put over the intact hemisphere. In the 10/20 EEG system, primary motor cortex is compatible with C3/C4 points. In the second 30 minutes of stimulation, each patient's dorsolateral prefrontal cortex will be stimulated. Anode electrode will be placed over the left dorsolateral prefrontal cortex and cathode electrodes will be put just above the right mid-orbital area. In the 10/20 EEG system, left dorsolateral prefrontal cortex is compatible with F3 point. In both sessions, real stimulation will rise from zero to two milliamperes in 30 seconds, continue at two milliamperes for 30 minutes, and decline from two to zero milliamperes in 30 seconds. Intervention 2: Control group: Brain stimulation will be done through a battery-driven constant current stimulator. Each patient's brain will be stimulated in five sessions in five consecutive days for about an hour per session. In the first 30 minutes, primary motor cortex will receive shaml stimulation. Anode electrode will be placed over the injured hemisphere and cathode electrode will be put over the intact hemisphere. In the 10/20 EEG system, primary motor cortex is compatible with C3/C4 points. In the second 30 minutes of stimulation, each patient's dorsolateral prefrontal cortex will receive sham stimulation. Anode electrode will be placed over the left dorsolateral prefrontal cortex and cathode electrodes will be put just above the right mid-orbital area. In the 10/20 EEG system, left dorsolateral prefrontal cortex is compatible with F3 point. In both sessions, stimulation will rise from zero to two milliamperes in 30 seconds, continue at zero milliamperes for 30 minutes, and decline from two to zero milliamperes in 30 seconds.
public Shahram Oveisgharan
North Kargar St
Tehran Iran (Islamic Republic of) +98 21 8490 2224 shogh2@yahoo.com Shariati hospital Tehran University of Medical Sciences scientific Shahram Oveisgharan
North Kargar St
Tehran Iran (Islamic Republic of) +98 21 8490 2224 shahram.oveisgharan@rush.edu Shariati hospital Tehran University of Medical Sciences Iran (Islamic Republic of) Inclusion Criteria: Stroke patients whose symptoms start within the last 4 days; stroke patients who suffer from upper extremity paresis due to stroke. Exclusion criteria: stroke patients with decreased level of consciousness; patients with metal foreign bodies in their heads; patients who do not sign the consent forms; patients who can not come regularly for three months after their first visit;patients with dementia before current stroke; patients who develop severe global aphasia or dementia after stroke. 20 years 90 years Both I63 Cerebral Infarction Rehabilitation Rehabilitation Intervention group: Brain stimulation will be done through a battery-driven constant current stimulator. Each patient's brain will be stimulated in five sessions in five consecutive days for about an hour per session. In the first 30 minutes, primary motor cortex will receive real stimulation. Anode electrode will be placed over the injured hemisphere and cathode electrode will be put over the intact hemisphere. In the 10/20 EEG system, primary motor cortex is compatible with C3/C4 points. In the second 30 minutes of stimulation, each patient's dorsolateral prefrontal cortex will be stimulated. Anode electrode will be placed over the left dorsolateral prefrontal cortex and cathode electrodes will be put just above the right mid-orbital area. In the 10/20 EEG system, left dorsolateral prefrontal cortex is compatible with F3 point. In both sessions, real stimulation will rise from zero to two milliamperes in 30 seconds, continue at two milliamperes for 30 minutes, and decline from two to zero milliamperes in 30 seconds. Control group: Brain stimulation will be done through a battery-driven constant current stimulator. Each patient's brain will be stimulated in five sessions in five consecutive days for about an hour per session. In the first 30 minutes, primary motor cortex will receive shaml stimulation. Anode electrode will be placed over the injured hemisphere and cathode electrode will be put over the intact hemisphere. In the 10/20 EEG system, primary motor cortex is compatible with C3/C4 points. In the second 30 minutes of stimulation, each patient's dorsolateral prefrontal cortex will receive sham stimulation. Anode electrode will be placed over the left dorsolateral prefrontal cortex and cathode electrodes will be put just above the right mid-orbital area. In the 10/20 EEG system, left dorsolateral prefrontal cortex is compatible with F3 point. In both sessions, stimulation will rise from zero to two milliamperes in 30 seconds, continue at zero milliamperes for 30 minutes, and decline from two to zero milliamperes in 30 seconds. Upper extremity motor capacity. Timepoint: Before intervention, week 2, month 1, month 3. Method of measurement: Fugl-Meyer test. Upper extremity dexterity. Timepoint: Before intervention, week 2, month 1, month 3. Method of measurement: Action Research Arm Test. Disability in the daily activities. Timepoint: Before intervention, week 2, month 1, month 3. Method of measurement: Modified Rankin Scale. Tehran University of Medical Sciences - Approved 2017-02-04 Tehran University of Medical Sciences Keshavarz Blvd Tehran Iran (Islamic Republic of)