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IRCT2014060917684N3 IRCT 2014-11-10 Shiraz university of medical science, Vice chancellor for research The effect of Pilocarpine on absorbed salivary gland dose in patients on radioiodine therapy. Studying the effect of using oral pilocarpine on absorbed salivary gland dose and side effects in patients on radioiodine therapy 2014-11-01 anticipated 20 Complete https://irct.ir/trial/16195 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 2-3 Thyroid Cancer therapy with I-131. Intervention 1: Intervention group:Using oral Pilocarpine every 8 hours, start at 2 hours after administration of radioiodine. Intervention 2: Control group:Using oral Placebo every 8 hours, start at 2 hours after administration of radioiodine.
public Nuclear medicine and molecular imaging research center
Nuclear Medicine department, Namazi Hospital, Namazi Square
Shiraz Iran (Islamic Republic of) 11351-71937 +98 71 1612 5330 nmmirc@yahoo.com Shiraz university of medical science scientific Nuclear medicine and molecular imaging research center
Nuclear Medicine department, Namazi Hospital, Namazi Square
Shiraz Iran (Islamic Republic of) 11351-71937 +98 71 1612 5330 nmmirc@yahoo.com Shiraz university of medical science Iran (Islamic Republic of) Inclusion criteria: Patients with diagnosis of hyperthyroidism or thyroid cancer who are candidate for radioiodine therapy Exclusion criteria: patient with history of uncontrolled asthma; bronchospasm; severe COPD; heart failure; acute iritis; close angle glaucoma; pateint use antihypertensive drugs; history of salivary gland disease; no patient consent. 20 years 65 years Both C73-C75 Malignant neoplasms of thyroid and other endocrine glands Prevention Prevention Intervention group:Using oral Pilocarpine every 8 hours, start at 2 hours after administration of radioiodine. Control group:Using oral Placebo every 8 hours, start at 2 hours after administration of radioiodine. Organ dose per administered I131 Activity (ODPA). Timepoint: 1,2,3,4,5,13,25,48 h after receiving radio-iodine 131. Method of measurement: By scintigraphy and MIRD Schema software calculations. Side effects of radio-Iodine 131. Timepoint: Every 4-6 weeks. Method of measurement: Asking the patient. Shiraz university of medical science, Vice chancellor for research Approved 2014-05-20 Shiraz university of medical science, Ethics Committee Central building of Shiraz University of Medical Science, Karimkhan-e Zand Boulevard Shiraz Iran (Islamic Republic of)