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IRCT201611242016N7 IRCT 2016-12-20 Vice Chancellor for Research and Technology Effect of different factors on the in-operative relief pain in root canal therapy Compariosn of the combination of premedication with ibuprofen plus inferior alveolar block plus buccal infiltration with inferior alveolar block plus buccal infiltration on anesthesia success of posterior mandibular teeth with irreversible pulpitis: A three blinded randomized clinical trial 2016-11-26 anticipated 100 Complete https://irct.ir/trial/1617 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Irreversible Pulpitis. Intervention 1: Ibuprofen: 1 capsule of 600 mg, 1 hour before the local anesthetic injection. Intervention 2: placebo: 1 capsule contain 500 mg lactos mono hydrate, 1 hour before the local anesthetic injection.
public Dr. Abbas Pardakhti
Tahmasbabad cross road, Vice Chancellor for Research and Technology building
kerman Iran (Islamic Republic of) +98 34 3226 3815 kmu_research@yahoo.com Vice Chancellor for Research and Technology scientific DR. Masoud Parirokh
Endodontic Department, School of Dentistry, Shafa street
Kerman Iran (Islamic Republic of) +98 34 3245 7931 masoudparirokh@yahoo.com Endodontics Department, School of Dentistry Iran (Islamic Republic of) Inclusion criteria: Age 18 or more than 18 years, no contraindications to taking either Ibuprofen (history of any allergic reaction to aspirin, NSAIDS, or Lidocaine with Epinephrine, nasal polyp, history of peptic ulcers or GI bleeding, pregnancy and lactation, renal or hepatic disease), no history of GI disorders or ulcer, having no serious systemic disease. Exclusion criteria: no response to cold test, having sensitivity to percussion and palpation, having radiographic changes such as PDL widening, lack of vital pulp in coronal pulp chamber access cavity preparation, teeth with evidence of crack in their crown, having advanced periodontal disease, taking narcotic drugs or analgesic drugs in recent 24 hours before treatment. 18 years 80 years Both K04.0 Pulpitis Treatment - Drugs Placebo Ibuprofen: 1 capsule of 600 mg, 1 hour before the local anesthetic injection placebo: 1 capsule contain 500 mg lactos mono hydrate, 1 hour before the local anesthetic injection Response to cold test. Timepoint: Before taking drug, 1 hour after taking drug before anesthetic injection, after local anesthetic injecyion. Method of measurement: Cold spray. In-operative pain. Timepoint: In access cavity preparation and during treatment. Method of measurement: Using Visual Analogue Scale (VAS). Vice Chancellor for Research and Technology Approved 2009-05-18 The Ethic Committee of Kerman University of Medical Sciences Vice-chancellor for Research, Building of kerman University of Medical Sciences, Tahmaseb-abad cross, Jahad Street kerman Iran (Islamic Republic of)