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IRCT2017071117468N4 IRCT 2017-08-16 Vice chancellor for research, Yazd University of Medical Sciences The effect of clonidine on the tip shoulder pain and hemodynamic complications of laparoscopy The effect of oral clonidine on the shoulder tip pain and hemodynamic response of patients undergoing laparoscopic surgeries 2017-03-25 anticipated 60 Complete https://irct.ir/trial/16071 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: Subjects will allocate to two equal groups of control and intervention using stratificaton randomization method. N/A Condition 1: Laparoscopic cholecystectomy. Condition 2: Laparoscopic inguinal hernia repair. Intervention 1: In control group: Patients received placebo tablets in the same shape of the clonidine tablets and the same times with intervention group. Intervention 2: In intervention group: Patients received 0.2 mg oral Clonidine (CLONIDINE HCL 0.4MG TAB, Toliddaru, Iran) before induction. Then, other doses of drug (0.2 mg) will prescribe after being awake and 6 hour after that.
public Dr Hamid Mirhosseini
Anesthesia department, Paramedical institue, Imam Hossein square, Yazd
Yazd Iran (Islamic Republic of) +98 35 3624 5956 Mirhoseini.h@gmail.com Yazd University of Medical Sciences scientific Dr Hamid Mirhosseini
Anesthesia department, Paramedical institue, Imam Hossein square, Yazd
Yazd Iran (Islamic Republic of) +98 35 3624 5956 Mirhoseini.h@gmail.com Yazd University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: ASA grades II and III, males and females, adult patients aged 18 to 65 years scheduled Laparoscopic surgeries. Exclusion criteria: Lack of patient consent, history of bronchial asthma, diabetes and hypertension, patients allergic to clonidine, hypertensive and diabetic patients, severe coronary insufficiency, recent myocardial infection, concomitant use of monoamine oxidase inhibitors, tricyclic antidepressants or opioids. 18 years 65 years Both K80.2 K40 Calculus of gallbladder without cholecystitis Inguinal hernia Placebo Treatment - Drugs In control group: Patients received placebo tablets in the same shape of the clonidine tablets and the same times with intervention group. In intervention group: Patients received 0.2 mg oral Clonidine (CLONIDINE HCL 0.4MG TAB, Toliddaru, Iran) before induction. Then, other doses of drug (0.2 mg) will prescribe after being awake and 6 hour after that. Patient's pain intensity. Timepoint: Just after awaking, 4, 8, 12, 24 hours after operation and time of patient's discharge. Method of measurement: According to VAS rating score. Heart rates. Timepoint: Just before prescribing drug and induction, 4, 8, 12, 24 hours after operation and time of patient's discharge. Method of measurement: Will be recorded by Automatic Hemodynamic Monitoring. Mean arterial blood pressure. Timepoint: Just before prescribing drug and induction, 4, 8, 12, 24 hours after operation and time of patient's discharge. Method of measurement: Will be recorded by Automatic Hemodynamic Monitoring. Vice chancellor for research, Yazd University of Medical Sciences Approved 2012-01-04 Ethics committee of Yazd University of Medical Sciences Headquarters of University, Bahonar square, Yazd Yazd Iran (Islamic Republic of)