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IRCT2014042117374N1 IRCT 2016-10-03 Shiraz University of Medical Sciences Efficacy of green tea extract in the treatment of the patients with dry eye. Comparing the effect of green tea extract and artificial tear in control of clinical symptoms, tear production, tear film stability, health of ocular surface and meibomian gland in the patients with dry eye and meibomian gland dysfunction. 2014-05-15 anticipated 60 Complete https://irct.ir/trial/15992 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Dry eye. Intervention 1: Intervention group: Artificial tear eye drop, one drop, three times a day for one month+ Green tea eye drop, one drop, three times a day for one month. For preparation of green tea drop, we brewed green tea then add a good amount of protective substances Benzalkonium Chloride under sterile conditions, filtrated and autoclaved. Amount of protective substances obvious with preservative challenge test. Intervention 2: Control group: Standard treatment include artificial tear eye drop one drop three times a day for one month.

public Mehdi Zadmehr

Central building of the university, Across the Flestin street, Zand street, Shiraz.

Shiraz Iran (Islamic Republic of) 7134814336 +98 711230541019 vcrdep@sums.ac.ir Shiraz University of Medical Sciences scientific Dr Mahmood Nejabat

Central building of the university, Across the Flestin street, Zand street, Shiraz.

Shiraz Iran (Islamic Republic of) 7134814336 +98 711230541019 vcrdep@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Incliusion criteria included؛ Dry eye and meibomian gland dysfunction. Exclusion criteria included؛ Use of oral tetracyclines and corticosteroids in 3 months before study and all ophthalmic medication in one month before, Patients with other ocular surface disorders such as corneal surface damage, eyelid complications except blepharitis, any previous ocular surgery, history of drug allergy in eye , use of ophthalmic medication to treat other ophthalmic complication except dry eye and blepharitis, severe belepharitis and dry eye that require systemic treatment, Nasolacrimal duct system disorders such as punctal occlusion, Pregnancy and lactation, as well as patients taking systemic medications and systemic diseases affecting this study are excluded. 30 years 70 years Both VII Diseases of the eye and adnexa Treatment - Drugs Treatment - Drugs Intervention group: Artificial tear eye drop, one drop, three times a day for one month+ Green tea eye drop, one drop, three times a day for one month. For preparation of green tea drop, we brewed green tea then add a good amount of protective substances Benzalkonium Chloride under sterile conditions, filtrated and autoclaved. Amount of protective substances obvious with preservative challenge test. Control group: Standard treatment include artificial tear eye drop one drop three times a day for one month. Clinical symptom. Timepoint: Before the intervention, one month after the intervention. Method of measurement: The questionnaire included: symptoms of itching, Burning, Reduced vision, Foreign body sensation, Pains, photophobia, Redness. Tear production. Timepoint: Before the intervention, one month after the intervention. Method of measurement: Shirmer test. Tear film stability. Timepoint: Before the intervention, one month after the intervention. Method of measurement: Tear Film Brake Up Time test. Ocular surface health. Timepoint: Before the intervention, one month after the intervention. Method of measurement: Staining of the cornea and conjunctiva. Meibomian glangd safety. Timepoint: Before the intervention, one month after the intervention. Method of measurement: Color and quality of gland secretion. Drug allergy. Timepoint: Before the intervention, one month after the intervention. Method of measurement: Clinical symptom. Eye infection. Timepoint: Before the intervention, one month after the intervention. Method of measurement: Clinical symptom. - - Shiraz University of Medical Sciences Approved 2014-01-28 Shiraz University of Medical Sciences Ethics committee Central Building of the University, Across the flestin street, Zand street, Shiraz, Fars. Shiraz Iran (Islamic Republic of)