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IRCT2016061416925N2 IRCT 2016-10-26 Shiraz University of Medical Sciences Effect of Origanum Vulgaris L. on Allergic Rhinitis. Assessment of Origanum Vulgaris L. Effect on Allergic Rhinitis Compared to Placebo: a randomized-controlled clinical trial. 2016-11-01 anticipated 110 Complete https://irct.ir/trial/15702 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Allergic Rhinitis. Intervention 1: Intervention group uses Origanum Vulgaris L. Extract; nasal spray, 40g/20ml, 2 puff, 3 times/day, for 1 month. Intervention 2: Control group uses placebo for 1 month.
public Seyed Morteza Emami Alorizi
Shiraz University of Medical Sciences, Zand Ave., Shiraz, Fars, Iran.
Shiraz Iran (Islamic Republic of) 713451978 +98 71 3230 5410 smemami@sums.ac.ir, morteza.emami@ymail.com Shiraz University of Medical Sciences scientific Seyed Hesamedin Nabavizade
Namazi Hospital, Zand St, Shiraz, Iran.
Shiraz Iran (Islamic Republic of) 719335899 +98 71 3612 2267 drhesamnabavi@yahoo.com Allergy Research Center. Iran (Islamic Republic of) Inclusion criteria: men and women aged 18 to 60 years old; outpatients with a history or diagnosis of allergic rhinitis for at least 6 months before the first visit; allergic rhinitis and the numbers of eosinophil in the nasal mucous or the skin Prick test is proven (if not already done during the last 6 months); signing informed consent; patients with a diagnosis of allergic rhinitis are previous topical or systemic treatments include antihistamines and corticosteroids have not responded or those with complications who have had previous with these drugs, do not want or cannot be treated with these drugs are; no anatomical abnormalities in the nose (nasal polyp or severe deviation); drugs that are used to treat allergies and if they use, it must be discontinued before the study; patients who are able to read and understand the consent form; ; patients who have not dementia; are not pregnant or are able to communicate and patients without nasopharyngeal tumors; patients who have not a history of drug allergy with Origanum vulgare. Exclusion criteria: patients taking drugs other than drugs that must consume according to the research plan, the duration of the project will be excluded from use; patients during the study have a fungal, viral or bacterial disease; patients who do not follow the recommended instructions will be excluded. 18 years 60 years Both J30-J39 Other diseases of upper respiratory tract Treatment - Drugs Placebo Intervention group uses Origanum Vulgaris L. Extract; nasal spray, 40g/20ml, 2 puff, 3 times/day, for 1 month. Control group uses placebo for 1 month. The overall clinical symptoms. Timepoint: Before the intervention and after intervention once a week, for a month. Method of measurement: Rhinitis Quality of Life Questionnaire. Severity of rhinorrhea. Timepoint: Before the intervention and after intervention once a week, for a month. Method of measurement: Rhinitis Quality of Life Questionnaire. Severity of itchy nose. Timepoint: Before the intervention and after intervention once a week, for a month. Method of measurement: Rhinitis Quality of Life Questionnaire. Severity of nasal obstruction. Timepoint: Before the intervention and after intervention once a week, for a month. Method of measurement: Rhinitis Quality of Life Questionnaire. Frequency of sneezing per day. Timepoint: Before the intervention and after intervention once a week, for a month. Method of measurement: Rhinitis Quality of Life Questionnaire. Severity of itchy palate. Timepoint: Before the intervention and after intervention once a week, for a month. Method of measurement: Rhinitis Quality of Life Questionnaire. Severity of eye symptoms. Timepoint: Before the intervention and after intervention once a week, for a month. Method of measurement: Rhinitis Quality of Life Questionnaire. Number of nose palate eosinophils. Timepoint: Before the intervention and after intervention once a week, for a month. Method of measurement: Rhinitis Quality of Life Questionnaire. Assessment of allergic rhinitis symptoms recovery based on the international diagnostic criteria of rhinitis quality of life questionnaire. Timepoint: Before the intervention and after intervention once a week, for a month. Method of measurement: Questionnaire. Shiraz University of Medical Sciences Approved 2016-08-07 Shiraz University of Medcal Sciences Shiraz University of Medcal Sciences(Central Building), Zand Ave. Shiraz Iran (Islamic Republic of)