]>
IRCT2014030516854N1 IRCT 2014-07-11 Vice Chancellor for Research, Gonabad University of Medical Sciences The comparison of effect of clonidine and fentanyl premedication on blood pressure and pulse rate changes in opium depended patient after indotracheal intubation Comparison of hemodynamic indices during endotracheal intubation after receiveing Clonidine and Fentanyl premedication in opium dependent patients 2013-10-07 anticipated 60 Complete https://irct.ir/trial/15652 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: The samples were randomly divided into two groups of Fentanyl and Clonidine. 2-3 opioid dependency. Intervention 1: In the clonidine group, Patients are given oral clonidine with dose of 3 – 5 microgram/kg, 60 minutes before endotracheal intubation. Intervention 2: in the Fentanyl group, Fentanyl 1 microgram/kg is injected intravenously 5 minutes before indotracheal intubation.
public Ali Reza Talai
15 Khordad Hospital Beydokht, shafa square, Gonabad
Gonabad Iran (Islamic Republic of) 9691793718 +98 53 3722 3028 talai.a@gmu.ac.ir 15 Khordad Hospital Beydokht scientific Dr Arash Hamzei
Gonabad University of Medical sciences , Dr Mehdizade street , Pardise
Gonabad Iran (Islamic Republic of) 9691793718 +98 53 3722 3028 arash_hamzei@gmu.ac.ir Gonabad University of Medical Iran (Islamic Republic of) Inclusion criteria: Age range of 18-65 years old؛ Candidate for elective surgery and those who were in ASA class of 1 and 2؛ The drug-dependent patients based on our definitions؛ No history of other addictive materials such as alcohol and psychoactive drugs؛ ptients should not have any anxiety disorders. Exclusion criteria: Any cardiovascular problems and arrhythmias during intubation؛ Over once to attempt intubation that may take more than 20 seconds؛ Any problem during intubation and surgery in which necessary interventions and desired measurements be impossible. 18 years 65 years Both F10 Mental and behavioural disorders due to use of opioids Treatment - Drugs Treatment - Drugs In the clonidine group, Patients are given oral clonidine with dose of 3 – 5 microgram/kg, 60 minutes before endotracheal intubation. in the Fentanyl group, Fentanyl 1 microgram/kg is injected intravenously 5 minutes before indotracheal intubation Systolic blood pressure and diastolic blood pressure. Timepoint: Before intubation, immediately after intubation and 5 minutes after intubation. Method of measurement: Measurement of blood pressure using a mercury sphygmomanometer. Heart rate. Timepoint: Before intubation, Immediately after intubation and 5 minutes after intubation. Method of measurement: Radial pulse counting with second time. Vice Chancellor for Research, Gonabad University of Medical Sciences Approved 2014-03-12 Ethics Committee of Gonabad University of Medical Sciences Gonabad University of Medical sciences , Dr Mehdizade street , Pardise Gonabad Iran (Islamic Republic of)