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IRCT2014020616506N1 IRCT 2014-03-18 Shiraz University of Medical Sciences- Vice Chancellor for research Assess of effect of oral vitamin E on increase of In Vitro Fertilization success in infertile men Assess of effect of oral vitamin E on increase of In Vitro Fertilization success in infertile men 2014-05-01 anticipated Complete https://irct.ir/trial/15426 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Male infertility. Intervention 1: Interventiion group: 400 IU Vit E will be given orally to 60 infertile men for two months before IVF. Intervention 2: Control group: similar shape placebo will be given orally to 60 infertile men two months before IVF.
public Niloofar Borzou
Iran, Shiraz, Shahid Faghihi Hospital, Department of OB-GYN
Shiraz Iran (Islamic Republic of) +98 71 1227 9715 borzou@sums.ac.ir Shiraz University Of Medical Scienses scientific Dr. Bahia Namavar Jahromi
Department of OB-GYN, Shahid Faghihi Hospital, Shiraz, Iran.
Shiraz Iran (Islamic Republic of) +98 71 1227 9715 namavarb@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Inclusion conditions: 120 of the patients who have been candidated for IVF due to male infertility, have been diagnosed through the semen analysis upon WHO’s criteria and have satisfied the conditions of performing IVF based on existing criteria ( i.e. after semen processing, it contains less than 1-2 million motile sperms, or less than 10 million motile sperms in addition to more than 2 years infertility without any response to IUI ) will be studied. Exclusion conditions: If people are not willing to cooperate in the project or consuming vitamin E, for any reason and also show any sensitivity to vitamin E, will be excluded from the project. 20 years 38 years Female N46 Oligospermia NOS Treatment - Drugs Placebo Interventiion group: 400 IU Vit E will be given orally to 60 infertile men for two months before IVF. Control group: similar shape placebo will be given orally to 60 infertile men two months before IVF. Comparison of sperm counts. Timepoint: After two mounts of treatment. Method of measurement: Semen analysis. Comparison of sperm motility. Timepoint: After two mounts of treatment. Method of measurement: Semen analysis. Comparison of the percentage of normal shape sperm. Timepoint: After two mounts of treatment. Method of measurement: Semen analysis. Comparison of clinical pregnancy rate. Timepoint: 6-8 weeks after IVF. Method of measurement: By follow up of the patients and sonography. Comparison of chemical pregnancy rate. Timepoint: 16-18 days after IVF. Method of measurement: By measurement of B-HCG. Shiraz University of Medical Sciences- Vice Chancellor for research Approved 2013-12-24 Shiraz University of Medical Sciences- Vice Chancellor for research Iran- Fars- Shiraz- Zand street- Central department- Shiraz University of Medical Sciences- Vice Chancellor for research Shiraz Iran (Islamic Republic of)