]>
IRCT201104121946N8 IRCT 2011-09-13 Vice Chancellor for research-Guilan University of Medical Sciences An assessment about impression of oral Methylnaltrexone on time of beginning of the bowel sounds after abdominal hysterectomy An assessment about impression of oral Methylnaltrexone on time of beginning of the bowel sounds after abdominal hysterectomy 2011-09-23 anticipated 66 Complete https://irct.ir/trial/1530 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Postprocedural disorders of genitourinary system, not elsewhere classified. Intervention 1: Intervention group: Oral Methylnaltrexone tablet (25mg); two hours before operation. After operation, bowel sounds in 12,13,….23,24 hours were listened every hour for one minute in right lower quaderant of abdomen and other measurements were checked. Intervention 2: Control group: Placebo oral tablet (25mg); two hours before operation. After operation, bowel sounds in 12,13,….23,24 hours were listened every hour for one minute in right lower quaderant of abdomen and other measurements were checked.
public Dr. Mandana Mansur Ghanaie
Reproductive Health research center-Alzahra hospital-Namjo street
Rasht Iran (Islamic Republic of) +98 13 1322 5624 m_m_ghanaie@yahoo.com Guilan University of Medical Sciences scientific Dr. Mandana Mansur Ghanaie
Reproductive Health research center-Alzahra hospital-Namjo street
Rasht Iran (Islamic Republic of) +98 911 131 3242 m_m_ghanaie@yahoo.com Guilan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria:1) women who were 35-55 years old (with ASA class I&II) .2) without history of susceptible diseases for post-operative nausea and vomiting for example peptic ulcer, gastritis and uses of chemotherapy's drugs. 3) Lack of history about chronic constipation , IBS and IBD. 4) Without history of drug reaction to Naltrexone , another drugs, foods and seasonal allergies or asthma. 5) Lack of kidney's diseases.6) lack of liver's diseases especially hepatitis. 7) lack of addiction to opioids (Tramadol, Morphine, Percocet) and alcohol.8) lack of using psychological drugs/pain reliefer with Codeine or Propoxyphene/ Clonidine/ Disulfiram/ Laxative/ Immunosuppress drugs/ thyroglobulin for diagnose Hashimoto's thyroiditis or hypothyroidism.9) Without history for laparatomy twice or more than. 10) lack of lung's diseases. 11) Without history of organ's transplantation. Exclusion criteria: 1) duration of operation more than two hours.2) existence of another operation accompanied by hysterectomy.3) incidence of oparation's or anesthesia's side-effects.4) hypertension. 35 years 55 years Female N99 Postprocedural disorder of genitourinary system, unspecified Treatment - Drugs Treatment - Drugs Intervention group: Oral Methylnaltrexone tablet (25mg); two hours before operation. After operation, bowel sounds in 12,13,….23,24 hours were listened every hour for one minute in right lower quaderant of abdomen and other measurements were checked. Control group: Placebo oral tablet (25mg); two hours before operation. After operation, bowel sounds in 12,13,….23,24 hours were listened every hour for one minute in right lower quaderant of abdomen and other measurements were checked. An assessment about impression of oral Methylnaltrexone on time of beginning of the bowel sounds after abdominal hysterectomy. Timepoint: 12 hours after operation, every hour. Method of measurement: Patient visits, listening to bowel sounds. Assessment of median time of beginning of the bowel sounds. Timepoint: Assessment of median time of beginning of the bowel sounds in first group (patients that received oral Methylnaltrexone). Method of measurement: Patient visits, listening to bowel sounds. Determination of frequency of urinary retention. Timepoint: After fully discharge. Method of measurement: Assessment about patient's ability to urinating. Determination of frequency of constipation. Timepoint: after surgery. Method of measurement: Patient visits, question about defecation. Determination of frequency of vomiting. Timepoint: after surgery. Method of measurement: Patient visits, question about vomiting. Determination of frequency of itching. Timepoint: after surgery. Method of measurement: Patient visits, question on base of itching score. Determination of frequency of ileus. Timepoint: 12 hours after operation, every hour. Method of measurement: Patient visits, listening to bowel sounds. Determination of frequency of side-effects (abdominal pain, bloating ,nausea ,hyperthermia, vertigo ,hypotension). Timepoint: after surgery. Method of measurement: Patient visit and examine. Vice Chancellor for research-Guilan University of Medical Sciences Approved 2011-05-28 Vice chancellor for research-Guilan University of Medical Sciences Vice chancellor for research-opposite of Azodi Studium-Namjo street Rasht Iran (Islamic Republic of)